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Consider it a testament to the ubiquity and flexibility of the endocannabinoid system: we can inhale medicinal cannabinoids via combustion or vaporization; ingest them via food or drink; and absorb them directly through the skin, the bodys largest organ. This latter category is broader and more complex than many of us give it credit for. Inside the mouth, it includes both buccal (between the gums and cheek, as with a lozenge) and sublingual (under the tongue, as with a tincture) modes of absorpt
A new study from an industry advocacy group in California examines the content of dozens of unregulated intoxicating “hemp” products that are easily available in the Golden State despite being banned by state law. The study, entitled The Great Hemp Hoax , was released Feb. 13 by the San Diego/Imperial Counties Joint Labor Management Cannabis Committee made up of representatives of UFCW Local 135 , and local companies March & Ash and Embarc.
Every five months Irvin Rosenfeld gets a FedEx shipment, courtesy of the federal government, containing six metal canisters, each with 300 perfectly rolled joints of what today would be considered rather mediocre weed. But the quality of the government-issue reefer matters less than the fact that Uncle Sam has been supplying him with it regularly since 1982, when Rosenfeld won the right to smoke cannabis for reasons of medical necessity under the auspices of the federal government’s Compas
Dr. Andrew Weil is the founder and director of the Arizona Center for Integrative Medicine at the University of Arizona College of Medicine. His early publications ( The Natural Mind and From Chocolate to Morphine ) focused on exploring altered states of consciousness. He is the author of several bestselling books, including Spontaneous Healing (1995), Eating Well for Optimum Health (2000), and Healthy Aging (2007).
Every five months Irvin Rosenfeld has gets a FedEx shipment, courtesy of the federal government, containing six metal canisters, each with 300 perfectly rolled joints of what today would be considered rather mediocre weed. But the quality of the government-issue reefer matters less than the fact that Uncle Sam has been supplying him with it regularly since 1982, when Rosenfeld won the right to smoke cannabis for reasons of medical necessity under the auspices of the federal government’s Co
Dr. Mark A. Scialdone, a recognized expert in the field of organic chemistry who specializes in natural product chemistry, is an inventor of 37 issued US patents and the author of 17 peer-reviewed articles in science publications. From 1994 to 2013, he was employed as a principal investigator at DuPont Central Research and Development. Dr. Scialdone is a founding member of the Cannabis Chemistry Subdivision of the American Chemical Society from which he received the 2018 CANN-CHAS Heidolph Award
It was once a common assumption within the cannabis community that plant cannabinoids aren’t “activated” or useful until they are “decarbed” — short for decarboxylated — which refers to the process of heating cannabis before it is consumed. But that notion has proven to be way off the mark. The major and minor cannabinoids in raw, unprocessed cannabis plants are found in their acid form: THCA, CBDA, CBGA, CBCA, and THCVA.
Pain, anxiety, and sleep are major drivers of medical cannabis use. But gastrointestinal symptoms, such as nausea and upset stomach, aren’t far behind. 1 Even small doses of cannabis can soothe the stomach and stimulate the appetite. In fact, of the four cannabis-derived drugs approved so far by the U.S. Food and Drug Administration, three are prescribed for the treatment of chemotherapy-induced nausea and vomiting.
Cannabis is supposed to be relaxing and fun. What’s not to like about giggles, munchies, and a brief break from the mundane? Unfortunately, the news from California’s Emerald Triangle is anything but upbeat these days. Report after report portends doom with headlines like “the world’s largest legal weed market is going up in smoke ” (The Economist), “California pot industry facing ‘ extinction event ‘” (SF Gate), and “ Despair in Emerald Triangle as CA legal cannabis collapses” (CalM
Project CBD recently reported on studies indicating that cannabis terpenes — the compounds that give the plant its robust and distinctive smell — activate the CB1 cannabinoid receptor. What’s more, in the presence of THC (also a CB1 agonist), terpenes appear to modulate cannabinoid activity in varied and interesting ways. 1,2 Today we focus on spicy-peppery beta-caryophyllene (BCP), one of the most common cannabis terpenes, which acts on several targets that impact the endocannabinoi
Biblical scholars have written about the role of cannabis as a sacrament in the ancient Near East and Middle East. Archeological evidence confirms the use of the plant in fumigation rituals in ancient Israel. Scriptural references indicate that cannabis was a key ingredient in the holy anointing oil employed in religious rites. But Yahweh, the Almighty Jealous God, frowned upon the idolatrous use of cannabis, the polytheistic drug of choice.
Ten years ago, most cannabis consumers couldn’t tell a terpene from a cannabinoid. But today things are different. Cannabis flower is categorized according to terpene profile. Product manufacturers add terp blends back into edibles and concentrates. Limonene is practically a household name. And for good reason. Sure, terpenes impart desirable flavors and aromas.
Special glands protruding from cannabis flowers express a series of unique molecules. Cannabinoids, as they are known, exist in cannabis. But it turns out that identical molecules are present in non-cannabis plants, as well. Researchers from Israel’s Weizmann Institute recently reported that they found cannabigerolic acid (CBGA) and other rare cannabinoids in Helichrysum umbraculigerum, a perennial shrub informally known as the woolly umbrella. 1 A South African Botanical Ferdinand Bohlmann and
In 2013, Noriko Shinjyo, Ph.D., a Research Associate at Chiba University in Japan, coauthored a study with Italian scientist Vincenzo Di Marzo on cannabichromene (CBC), a phytocannabinoid that exerts profound effects on the nervous system. 1 Published in Neurochemistry International , their paper probed how CBC influences the fate of adult neural stem progenitor cells, which are described as “an essential component of brain function in health as well as in pathology.” As stem cells m
This transcript is adapted from CannMed’s weekly podcast , hosted by Ben Amirault, who recently interviewed Bonni Goldstein, MD, one of the country’s most respected and experienced medical cannabis physicians. Dr. Goldstein has treated thousands of patients with medical cannabis. She is the medical director of Canna-Centers Wellness & Education and the clinical advisor to Cannformatics.
If you’ve been to our website before, you’ll see it’s much easier to navigate now, thanks to the talented folks at Blue Dream , Ganjapreneur’s in-house creative agency. You’ll also see that we have significantly increased our medical conditions-related content. “The new Project CBD website is designed to make their educational content more accessible and discoverable,” explained Noel Abbott, CEO of Ganjapreneur and strategic advisor for Blue Dream. ̶
Cannabinoid receptors CB1 and CB2 are the definitive and best-known targets of endogenous and plant-derived cannabinoids, but they’re far from the only ones. Several phytocannabinoids, including cannabidiol (CBD), for example, and the two primary endocannabinoids — anandamide and 2-AG — have been shown to interact with peroxisome proliferator-activated receptors, or PPARs 1 (pronounced pee-parrs ), which are found on the surface of the cell’s nucleus.
For all modern medicine can do, many mysteries remain unsolved. What is long COVID? Is there really such thing as a “cure” for cancer? And how to explain the surprisingly high prevalence of fibromyalgia, a debilitating, lifelong disorder of the central nervous system without a known cause that affects between 2 and 4 percent of adults worldwide? In the absence of an answer — or a cure — treatment is the name of the game for fibromyalgia.
HerbalGram, the acclaimed quarterly journal of the American Botanical Council, recently published its 2021 “Herb Market Report,” which included data on sales of CBD as an herbal ingredient in mainstream and natural retail channels in the United States. The combined total from both channels — $58,293,034 — does not include CBD sales in licensed cannabis dispensaries or CBD products, such as vapes, tinctures, gummies, and other edibles sold online.
Have you heard of Celtic Hemp? In a recently published paper in Cannabis and Cannabinoid Research , Dr. John M. McPartland and Saoirse E. O’Sullivan trace hemp’s prehistoric journey from Asia to Hibernia — now modern-day Ireland. Like much of Europe, cannabis arrived in Ireland when written records were scarce. The authors rely on archeological, linguistic, and pollen analyses as they document the migration of cannabis across Europe.
At first glance, Cannabis Textiles is a quiet, unassuming book, without slick, staged photos or superlative descriptions of indigenous cultures. Such simplicity reflects the book’s inner beauty, which documents the history of a disappearing handcraft, that of traditional hemp cultivation and fabric production. Skoglund’s book focuses primarily on indigenous hemp cultures in Europe and Asia.
I was fortunate to cross paths with Raphael Mechoulam, “the father of cannabis research,” at several science conferences over the years. The most memorable occasion was the 22nd annual meeting of the International Cannabinoid Research Society (ICRS) in Freiburg, Germany, in July 2012. Mechoulam delivered a plenary speech at the symposium, addressing the future of cannabinoid research and key areas of study that should be pursued.
Recently my wife returned from a night out with a ringing in one ear and significantly diminished hearing. It was a sure sign of injury caused by standing too close to a speaker. She was upset with herself for being so careless and concerned that the condition would persist. For the next couple days, she got extra sleep to aid recovery, and for good measure took an extra dose or two of CBD.
This is first of an occasional column that updates developments pertaining to articles previously published by Project CBD. We start with some positive news from the Golden State. Then a follow-up on our investigative report about Curaleaf, the world’s biggest cannabis company. And freedom of expression takes a hit when it comes to cannabis advocacy in the Czech Republic.
Curaleaf, the world’s largest cannabis company, is mired in scandals involving Russian oligarch money, product safety violations, and unfair labor practices.
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