Clinical Trial: Oral THC Administration Associated with Opioid-Sparing Effects

NORML

Trauma patients administered oral THC consume fewer opioids than do similarly matched controls, according to clinical trial data published in the journal Trauma Surgery & Acute Care. Investigators affiliated with the Saint Anthony Hospital and Medical Campus in Colorado assessed the impact of the off-label use of dronabinol (FDA-approved synthetic oral THC) on opioid consumption patterns in trauma patients with acute pain. Sixty-six patients participated in the study.

Clinical Trial: CBD Administration Reduces Heroin Cravings

NORML

The administration of oral CBD reduces cue-induced cravings and anxiety in subjects with a history of heroin use, according to clinical data published in The American Journal of Psychiatry. In clinical models, CBD administration has been shown to reduce cravings for tobacco. Investigators at The Mount Sinai Health System in New York City assessed the effect of CBD versus placebo in 42 drug-abstinent participants with a history of heroin use.

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Clinical Trial: Cannabinoid Administration Via a Metered-Dose Inhaler Is Safe and Effective for Chronic Pain Patients

NORML

The delivery of precise doses of THC via an inhaler is associated with pain mitigation in patients with neuropathy and other complex pain conditions, according to clinical trial data published in the European Journal of Pain. A team of Israeli researchers conducted a randomized placebo-controlled clinical trial to assess the safety and efficacy of a novel, metered-dose cannabis inhaler in 27 patients with chronic pain.

Clinical Trial: Transdermal Application of CBD Effective in Patients with Myofascial Pain

NORML

The transdermal application of plant-derived CBD reduces fascial pain in patients with temporomandibular disorders (TMD aka TMJ), according to clinical data published in the Journal of Clinical Medicine. Polish investigators conducted a randomized, double-blind placebo-controlled trial assessing the efficacy of twice-daily transdermal CBD administration on 60 patients with TMD over a period of 14 days.

Japanese Officials Approve Epidiolex For Clinical Trials

Cannabis Law Report

The trials, to be tightly controlled in a hospital environment, are exempted from Japan’s Cannabis Control Act, which bans cannabis compounds generally. Ministry of Health, Labor and Welfare officials recently announced the trials during a meeting of the Okinawa-Northern Task Force, a research and development agency. Japanese officials approve Epidiolex for clinical trials.

Treating addictions with psychedelic psychotherapy

Cannabis Life Network

Imagine having a treatment-resistant addition. You’ve tried going to therapy, taking medications, receiving treatment at rehabilitation centres–everything. But none of it worked. Where do you even go from there? What else is there to do?

InMed Submits Clinical Trial Application to Evaluate INM-755 in Phase 1 Trial

Puff Puff Post

5, 2019 /CNW/ – InMed Pharmaceuticals Inc. (“InMed” or the “Company”) (TSX: IN; OTCQX: IMLFF), today announced the filing of a Clinical Trial Application (“CTA”) in the Netherlands to initiate a Phase 1 human clinical trial for INM-755 in healthy volunteers. ” “This is a significant milestone for the Company as we transition from a preclinical to a clinical stage organization,” says Eric A.

FDA Approves Marijuana-Based Epilepsy Drug For Use On Kids In Clinical Trials

Otherside Farms

Federal regulators have approved two clinical studies testing whether a marijuana-based epilepsy drug may help prevent seizures among epileptic children. Our definition of pure is no THC,” Guy said, adding that clinical study would help provide “better understanding and experience in what cannabidiol does in these different children groups, what benefit we can see, and how the results can best be measured.”.

Are Marijuana Inhalers Most Effective Treatment For Chronic Pain?

The Fresh Toast

Cannabis Medical Marijuana News RX cannabis inhalers chronic pain clinical trials Neuropathy THCAre Marijuana Inhalers Most Effective Treatment For Chronic Pain? Metered-dose THC inhalers delivered consistent pain relief with minimal adverse effects for neuropathic patients, researchers found. The post Are Marijuana Inhalers Most Effective Treatment For Chronic Pain? appeared first on The Fresh Toast.

InMed Submits Clinical Trial Application to Evaluate INM-755 in Phase 1 Trial

Puff Puff Post

5, 2019 /CNW/ – InMed Pharmaceuticals Inc. (“InMed” or the “Company”) (TSX: IN; OTCQX: IMLFF), today announced the filing of a Clinical Trial Application (“CTA”) in the Netherlands to initiate a Phase 1 human clinical trial for INM-755 in healthy volunteers. ” “This is a significant milestone for the Company as we transition from a preclinical to a clinical stage organization,” says Eric A.

CBD for Brain-Damaged Babies?

Project CBD

The launch of a clinical trial examining the use of CBD in newborns suffering from hypoxic ischemic encephalopathy (brain damage caused by lack of oxygen) means new hope for the million plus babies born each year with this condition Giving medical cannabis to infants is a difficult taboo to shift, but new research is paving the way.

Can cannabis be a substitute for prescription drugs?

Leafly

In order for a prescription drug to reach the market, it must be extensively studied, first in animal and then in human clinical trials. Safety, efficacy, and risks must be determined. But as anyone who has seen a commercial for a prescription drug knows, there are still side effects.

Cannabinoids for Scleroderma

Project CBD

Two compounds that target the endocannabinoid system are currently in development to treat scleroderma – and they’re already in clinical trials. Pharmaceutical researchers have their sights set on developing a drug that bypasses CB1 while boosting CB2. Referred to as a “selective CB2 agonist ,” such a compound would appear to have potential as a treatment for scleroderma

Hooked on Weed? Try Nicotine Instead

Project CBD

Recently NIDA supported a clinical trial which used nicotine as a therapy for relatively mild cannabis withdrawal symptoms In its ongoing search for alternatives to recreational cannabis, the National Institute on Drug Abuse ( NIDA ) has been funding research into much more dangerous and addictive drugs — ostensibly to help people ween off cannabis.

“Candy Flipping” — Mixing MDMA and LSD — Is Hitting the Lab

Cannabis Law Report

Researchers have announced a phase 1 clinical trial of the popular drug combo. Ravers old and new will be well aware of this practice. “The … Read More. The post “Candy Flipping” — Mixing MDMA and LSD — Is Hitting the Lab first appeared on Cannabis Law Report.

Today’s Answer of the Day

TheAnswerPage

Are any pre-clinical trials or clinical trials evaluating the therapeutic benefits of CBD currently underway? According to ClinicalTrials.gov, there are more than 40 clinical trials in process to determine if CBD treatment mitigates the symptoms of various disorders/illnesses, including PTSD, alcohol use disorder, anxiety disorders, Sturge-Weber syndrome, pain, autism spectrum disorders, schizophrenia, muscle spasms and some cancers.

Marijuana Shows Promise In Sickle Cell Disease Treatment

The Fresh Toast

Clinical trial results indicate cannabis could provide an alternative or adjunctive treatment to sickle cell patients. Marijuana Shows Promise In Sickle Cell Disease Treatment.

Today’s Answer of the Day

TheAnswerPage

Clinical trials evaluating the use of human monoclonal antibodies against interleukin 1 and interleukin 6 to treat cytokine storm syndrome in COVID-19 patients are underway or in the planning stage.

The Best Organic CBD Oil in the UK

Cannabis Law Report

AS CBD continues to go from strength to strength, both in clinical trials and in the minds of the mainstream, the question of the best … Read More. Pot Luck

Today’s Answer of the Day

TheAnswerPage

A clinical trial evaluating this drug has begun in Italy.) Baricitnib, a drug approved for the treatment of rheumatoid arthritis, may reduce COVID-19 viral entry and mitigate inflammation. (A Does CBD interact with Baricitnib?

US Government Approves Increased Production of Marijuana for Clinical Research

NORML

Federal officials have approved plans for the University of Mississippi to grow 2,000 kilograms (4,409 pounds) of cannabis to provide to investigators for clinical trial research. Clinicians wishing to conduct FDA-approved clinical trials on cannabis have long complained that federally-provided samples are of inferior quality.

ASA offers solution to DOJ research block: Our comments on the DEA’s proposed rules

Americans for Safe Access

This new agency, the Office of Medical Cannabis Control (OMCC), would be tasked with overseeing not only the requirements of the research program, but would also enable cultivators that are already licensed in medical cannabis states to provide high quality medical cannabis to researchers, thereby increasing the diversity of products that can be used in research studies and clinical trials

DEA 163

Today’s Answer of the Day

TheAnswerPage

Excluding potential drug:drug interactions, what adverse effects of CBD have been noted in clinical trials? In clinical trials evaluating CBD, adverse effects, including diarrhea, somnolence, decreased appetite, change in weight, and increased levels of liver enzymes have been noted. Of note, the one FDA-approved CBD product is associated with a higher risk of hepatotoxicity necessitating recommended scheduled liver function testing in patients starting the medication.

Brain Awareness Week: CBD and the Brain

Leafwell

How it works and what effect it has on the body is not precisely known, partially because far more clinical trials need to take place before we can say anything for sure, and partially because research on cannabinoids – even the non-psychoactive/non-intoxicating ones – is still restricted in many parts of the world. Cannabidiol (CBD) is still a big mystery in many ways.

Canadian Researchers Studying Hemp Protein to Treat Hypertension

Leafly

"If the clinical trial shows that hemp can help reduce blood pressure, then other treatment areas will be examined.". The post Canadian Researchers Studying Hemp Protein to Treat Hypertension appeared first on Leafly. Canada Health Science & Tech Hemp research studies

Legislation To Produce And Research Cannabis Introduced

NORML

A bipartisan coalition of House lawmakers has introduced The Medical Cannabis Research Act of 2019 ( HR 601 ), to facilitate federally-approved clinical trials involving cannabis. The act ends the University of Mississippi’s existing monopoly on the growth of cannabis for clinical research purposes, by requiring the licensing of additional manufacturers.

Today’s Answer of the Day

TheAnswerPage

Transporting [marijuana] across states lines may not be lawful under state laws, unless a patient is participating in a clinical trial and has a letter that documents such participation.” According to the Controlled Substances Act, is it legal to transport marijuana across state lines from one medical marijuana legal state to another medical marijuana legal state?

Today’s Answer of the Day

TheAnswerPage

Is the US VA Office of research and Development conducting any clinical trials that evaluate the use of CBD for the treatment of PTSD? The trial will compare PE + CBD to PE + placebo in a sample of 136 military Veterans with PTSD at the VA San Diego Medical Center. A RCT evaluating the efficacy of using CBD as an adjunctive to prolonged exposure therapy (PE therapy)) was started in March 2019 and will conclude on September 30,2023.

CDC Seeks Public Comments Regarding Chronic Pain Management

NORML

” This finding is hardly a surprise, as cannabis is well-established to mitigate pain in clinical models, particularly in patients with neuropathy. Additional clinical trial data indicates that cannabinoids possess synergistic activity with opioids, which “may allow for opioid treatment at lower doses with fewer [patient] side effects.”

Cannabis 3.0 Accelerates Access to Consumer and Medical Research

Cannabis Law Report

Virtual Clinical Trials transcend geographic, mobility and economic barriers. Clinical trials are medical research projects involving human participants. The main goals with conducting clinical studies, which could include observational studies or clinical trials, are to explore the causes of a disease or its symptoms, test a treatment, and learn how a certain behaviour affects patients’ health. Authored By : Arundati Dandapani.

UK: NHS – The Minimalist Approach To Issuing Cannabis Reimbursements

Cannabis Law Report

Since a new law took effect a year ago, England’s National Health Service (NHS) has reimbursed patients on only 18 occasions for “unlicensed” cannabis-based products that have not undergone clinical trials, according to government data. They’re also known as “specials,” meaning they did not go through clinical trials to be granted a license to be marketed.

Kristin & Shelby – Fighting Dravet Syndrome

Leafwell

This is how Kristin Wilcox describes the effect a cannabis-infused drug given to her daughter, Shelby Mathews, during a clinical trial on cannabinoids for Dravet Syndrome. “I saw a change almost immediately. I can’t even explain … I can’t even describe it, but it was … It was like a light started coming back into her eyes.”

Today’s Answer of the Day

TheAnswerPage

Do the results of randomized clinical trials support those claims? According to reports in the media and statements on various CBD websites, CBD has anti-depressant effects. April 2019 systematic review on the role of cannabidiol in psychiatry found that CBD has no efficacy in depression and bipolar disorders. Preclinical studies have shown that CBD has anti-depressant effects in genetic rodent models of depression. See Answer. See Answer.

Review Paper: Clinical Evidence Lacking in Support of CBD as an Anti-Viral Agent

NORML

There is an absence of clinical data supporting the efficacy of CBD as an antiviral agent, according to a systematic literature review published in the journal Cannabis and Cannabinoid Research. By contrast, they reported that there exists “no evidence from properly designed clinical trials to support the use of CBD for the treatment” of these or other conditions, such as the flu, West Nile virus, Ebola, or common cold viruses.

Study: Marijuana Provided For FDA-Approved Clinical Research Genetically Similar to Hemp

NORML

Marijuana grown by the University of Mississippi for clinical research purposes is genetically divergent from strains of cannabis commercially available in retail markets, according to an analysis prepared by researchers at the University of Northern Colorado. Clinicians wishing to conduct FDA-approved clinical trials on cannabis have long complained that federally-provided samples are of inferior quality.

Survey: Three Of Four Military Veterans Would Consider Using Medical Cannabis

NORML

Proposed federal legislation to direct the agency to conduct clinical trials on the use of cannabis for PTSD and for other conditions is currently pending in the US House and Senate. Seventy-five percent of military veterans say that they would consider using either “cannabis or cannabinoid products as a treatment option,” according to member survey data compiled by the group Iraq and Afghanistan Veterans of America (IAVA).

Not-very-NICE: UK Cannabis Policy and Harm to Patients

CannaTech

This commentary on the NICE UK cannabis guidelines is originally published by The Academy of Medical Cannabis , the globally leading institute for clinical training and research in cannabis-based medicinal products. The supportive regulatory environment has facilitated a mounting body of clinical and transnational research demonstrating the efficacy of medically prescribed marijuana.