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Continue reading Why Patients Should Always Start With Microdosing Medical Marijuana at The Fresh Toast. Cannabis How-To Medical Marijuana RX microdosingFinding the right dose of a new medication can be tricky. The same is true of medical cannabis. MORE
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. People have been using cannabis as medicine for years. Sadly, many have had to keep their use hidden due to outdated laws and misdirected societal norms. MORE
Microdosing, if you have not yet heard of it, is hotter than just any ordinary trend: Science proves THC and CBD safe, with very real benefits associated with consuming very low doses regularly, as opposed to massive doses all at once. What is a Microdose? Purpose of Microdosing. MORE
The other trial will test LSD microdosing as an ADHD treatment. Mind Medicine, Inc. , a Canadian biotech firm, is entering Phase II clinical trials for two experimental treatments. According to its website, one trial involves an ibogaine-derived drug for treating opioid addiction. The company hasn’t yet generated revenue, but it’s anticipating a $50 million valuation when it goes public. MORE
Microdosing is a technique that helps your body adjust to the doses you take by taking very small amounts periodically. Medical MORE
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. RELATED: A Handy Guide For Microdosing Weed. By: Connie Carey. Cannabis is my PTSD healer and my salvation from abuse and suicide. MORE
Not a dose, but a microdose! “My My girlfriend is microdosing it every evening via a vaporizer and it helps her a lot falling and staying asleep. By: Madeleine Balestrier: Marijuana and sleep; what’s the deal? Sleep is the holy grail of adulthood. . MORE
Microdosing cannabis allows users to experience the health benefits of marijuana without getting too high. What is microdosing? When talking about microdosing cannabis, the same principle applies. What does microdosing do? RELATED: A Handy Guide For Microdosing Weed. MORE
Microdosing is a method of dosing cannabis in a way that allows you to reap its medical benefits without getting high. The other trend is a special approach to consuming cannabis, which was previously associated only with psychedelic substances—microdosing. Basics of microdosing. MORE
Business Culture Featured Interview Latest Legalization News Law Marijuana News Science Dana Larsen Medicinal Mushroom Dispensary microdose psilocybes psilocybin war on drugs MORE
” Stacie tried microdosing, taking smaller amounts of cannabis regularly throughout of the day to maintain a more balanced mood and eliminate her anxiety. Microdosing is individual to each person. “I microdose with edibles. MORE
They are quick to tell you to microdose and to not just use cannabis as an end all be all but that a holistic approach to wellness is key to optimum health! We have another amazing month full of eventful memories! Obi from Melting Point Extracts always in an amazing mood and full of knowledge! MORE
RELATED: A Handy Guide For Microdosing Weed. Today’s story comes from Michelle, a Miss Marijuana reader who uses marijuana for depression. She found that cannabis paired with CBD oil helped her beat her suicidal thoughts and stoped her from feeling depressed. MORE
Cannabis Dosing cannabis cooking CBD Oil cooking with marijuana dosing ingestion methods microdosingThere are many products with all sorts of ratios such as THC:CBD of 3:1, 1:20, 5:2 and so on. Yet, when people try these ratios out, they sometimes find that two products, even with the same ratios, can have widely different effects, and sometimes even no effect. MORE
Doctors are embracing an emerging trend called microdosing, when the user to moderate their mind by taking small doses throughout the day. Continue reading Microdosing Marijuana: What Doctors Say Is The Best Way To Consume at The Fresh Toast. Cannabis Medical Marijuana microdosing MORE
Cannabis Dosing CBD dosing microdosing THCWe are moving into a new world of MMJ. No longer is it just flowers, hash and edibles of varying degrees of quality. MORE
It seems unlikely, even if microdosing continues to trend. Last week, COMPASS Pathways announced its acquisition of US Patent No 10,591,175. What does that patent cover? Psilocybin! MORE
Each gummy is 5 milligrams, a “very popular microdose for beginning edible consumers,” he said. Tweet 1 has already come in… @ LtGovStratton ? buys Mindy’s edibles at the 6 am opening of cannabis store in Wrigleyville. She pays with a $100 bill. CNN report. MORE
To do microdoses, you’ll want to divvy that up into five to ten doses throughout the day and figure out the best way for you to take each dose. How Should I take my Microdose? You can also use a CBD-infused lotion to help with topical pain in addition to your microdose. MORE
Microdosing is a technique that helps your body adjust to the doses you take by taking very small amounts periodically. Medical MORE
When patients understand their disease state, how the endocannabinoid system interacts with all their other systems, comprehends the concept of microdosing, as well as the different components of different strains, and the many different methods of consumption available, we see amazing things. MORE
Cannabis Dosing cannabis cooking CBD Oil cooking with marijuana dosing ingestion methods microdosingThere are many products with all sorts of ratios such as THC:CBD of 3:1, 1:20, 5:2 and so on. MORE
In recent years, microdosing has gained popularity in the cannabis community. Still, you may be wondering: What is microdosing? Microdosing is the act of using a very small amount of a substance to feel minor, but still perceptible, sensations. When it comes to microdosing cannabis, the idea is not to get high–– as counter-intuitive as that may sounds––but rather to get the point where you are just on the verge of being high. How To Microdose Cannabis. MORE
Cannabis Dosing cannabinoids CBD dosing Edibles Effects of Marijuana microdosing side effects THCMedical marijuana, like any other medication, can have side-effects. Of course, side-effects such as being pain-free and being able to eat and sleep properly are positive ones. MORE
When it comes to microdosing, more than size matters. Arizona's Darwin Brands explain how their team customizes cannabis oil with microdosing in mind. The post Finding the Right Mix for Microdosing appeared first on Leafly. Strains & Products Darwin dosing edibles sponsored article vape pens MORE
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. . By Sarah H. . . I found B when I was very sick and smoking all day to manage my chronic pain and nausea, which was expensive and debilitating. As a college senior, my grades were nosediving and my future was looking bleaker every day. . . MORE
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. RELATED: A Handy Guide For Microdosing Weed. By: Dee Dussault. The word “busy” has to go. We are all busy. We are all filled up with information and tasks. MORE
While microdosing THC and CBD is a relatively new trend on account of marijuanas growing popularity, there is some clinical research suggesting that less is in fact more when it comes to medicinal Cannabis. There is no optimal dose for microdosing with Cannabis. MORE
Microdosing is Key. We want to remind patients that microdosing is important with vape pens. MORE
The post Open Mike Eagle’s Creative Super Powers Fueled by Microdosing appeared first on Leafly. Hip hop artist, comedian, and cultural force Open Mike Eagle compares recording on Kiva cannabis edibles to eating Dragonball-Z’s senzu beans. Podcasts Music products strains The Hash MORE
What if you could microdose CBD all night long? The CBD Pillow turns this sweet dream into a reality. The post Is CBD microencapsulation the next secret to sleep? appeared first on Leafly. CBD cbd CBD Pillow sleep sponsored article MORE
Right away, I thought to myself ‘that is the kind of guy who would make the ideal partner for a women-helmed and women-focused company,’ not to mention his microdosing product, Mom’s Formula, that is tailor-made for the women we serve.”. MORE
As more interest in CBD has led to more research, people have also begun wondering about the practice of microdosing. What is it, and how can it help medical marijuana patients? Cannabis Oil MORE
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. I decided to try it anyways and I decided to microdose it. I use Durban Poison to microdose about every other day. By: Jessica N. MORE
SEPTEMBER 10, 2019
Dr. Garcia-Romeu Comments on Recent Study of Psychedelic Microdosing in Rats. Dr. Albert Garcia-Romeu commented on a recent study at UC Davis which found that microdoses of DMT could ease depression symptoms in rats. MORE
While medical marijuana has gained significant recognition over the past several years for its ability to safely and effectively treat a variety of conditions, ranging from anxiety and pain to cancer and Crohn’s disease , doctors have only recently started to notice a secondary – and equally intriguing – result of medical cannabis use: Weight loss. As leading researchers summarize: The effect size of cannabis use on body mass index (BMI) is large and the magnitude of the difference in BMI of users and non-users is of clinical significance. Besides going against all the classic “munchies/stoner” stereotypes, this finding is especially puzzling as cannabis is often used to increase weight gain in patients with medical conditions such as HIV/AIDS and cancer. So why are medical marijuana patients gaining weight when they need to, but losing weight when they don’t? How is a phenomenon like this even possible? And, if it’s true – as studies suggest – what can patients do to harness the weight loss power of medical cannabis to improve their overall health? CannaMD answers all these questions and more in today’s post! Already know that medical marijuana is right for you? Head on over to our appointment page to get started with medical cannabis today! Marijuana & Obesity Rates. The current trend of cannabis-related weight loss seems to fly in the face of classic “stoner” stereotypes. Don’t marijuana users consume more calories? How could people who eat more possibly weigh less? Are cannabis users really more likely to have better weight-to-height ratios than non-users? Believe it or not, science says: YES. Take the American Journal of Epidemiology. In 2011, researchers published cross-sectional data from two population-based surveys including over 50,000 respondents. Although obesity rates in the two surveys were 22.0% and 25.3% among participants reporting no use of cannabis in the past 12 months, obesity rates dropped to 14.3% and 17.2% among participants who reported using cannabis at least three days per week. Importantly, these differences were not accounted for by tobacco smoking status. As the study authors note: The proportion of obese participants decreased with the frequency of cannabis use. After adjusting for sex and age, cannabis use was also associated with body mass index (BMI) differences in both samples, leading researchers to conclude: …despite the evidence that cannabis use stimulates appetite in clinical trials and laboratory studies, cannabis users are actually less likely to be obese than nonusers in the general population. As counterintuitive as it might sound, this conclusion is actually in line with a growing number of studies. For instance, in a 2005 review of 297 medical charts, the Journal of Addictive Diseases reported that the rate of cannabis use in the last 12 months was lower in obese subjects than in subjects with a lower BMI. While investigators initially took these results as “support for overeating as competition for drugs and alcohol in brain reward sites,” follow-up studies suggest they might actually be pointing towards something else. But before we move on to why this pattern is happening, it’s important to establish that it is in fact a pattern. Fortunately, a recent flurry of new studies makes our job easy. After reviewing 3,617 participants, the American Journal of Cardiology reports: More extensive marijuana use was associated with a higher caloric intake… but not with higher body mass index (BMI) and lipid and glucose levels. Researchers with peer-reviewed journal, Obesity , drew similar conclusions. After analyzing data from 786 participants, investigators found: Cannabis use was statistically associated with lower body mass index (BMI) and lower percent fat mass… after adjusting for numerous confounding variables. Also of interest, The American Journal of Medicine adds: We found significant associations between marijuana use and smaller waist circumferences. Perhaps most impressive, a 2018 meta-analysis of 11 high-quality research studies observed among the reviewed reports: …significantly reduced body mass index (BMI) and rates of obesity in cannabis users, in conjunction with increased caloric intake. Now that we know marijuana-related weight loss is actually a real thing, we’re faced with an even bigger question: How does it work? While scientists are still searching for a definitive explanation, researchers with Cannabis and Cannabinoid Research have an interesting theory. What About the “Munchies”? Before exploring theory details, one important point deserves attention: Marijuana users eat more than non-marijuana users (and yet still weigh less). Almost every study cited above highlights increased caloric intake among marijuana users. One group of researchers found: [U]sers who had consumed cannabis for more than 1,800 days over 15 years consumed on average 619 more calories/day than nonusers, yet showed no difference in BMI. Likewise, in a study of 10,623 U.S. adults aged 29-50, Public Health Nutrition reports: We found caloric intake to be higher among marijuana users than among non-current users and that the intake increased as frequency of marijuana use increased. Although energy intake was higher among marijuana users, their body mass index (BMI) was somewhat lower. The same study also found that heavy users (subjects who reported using marijuana 11 or more times a month) consumed 582 more calories a day than non-users. Analyzing a collection of similar research, Cannabis and Cannabinoid Research summarizes: Across these studies, on average, cannabis users consumed an additional 834?calories/day relative to nonusers. As the BMI of cannabis users is lower than non-users, this suggests that marijuana users must have increased metabolic rates – which brings us to the next piece of our puzzle. Marijuana & Metabolism. In 2018, researchers set out to propose the first theoretical explanation for the cannabis calorie increase/weight loss paradox. And while the terms may sound complicated, the idea is actually quite simple. (To cut to the “bottom line,” scroll to the bottom of this post!). A number of important biological systems , including metabolism, depend on our endocannabinoid system. The endocannabinoid system is made up of receptors (the most studied are CB1 and CB2 ) and chemical compounds called cannabinoids. There are two types of cannabinoids: Endocannabinoids (the type your body naturally produces) and phytocannabinoids (the type produced by cannabis plants). And the coolest part? Both types share a number of key similarities. Meaning marijuana cannabinoids can interact with our natural endocannabinoid system to influence important biological systems, such as metabolism! Maintaining proper endocannabinoid system tone for optimal metabolic functioning requires a nice balance of omega-6 (linoleum acid, LA) and omega-3 (?-linolenic acid, ALA) fatty acids. To keep our body burning and storing calories the way it should, we need a good omega-6/omega-3 ratio. Unfortunately, the standard American diet is defined by a super-abundance of calories from sugars and refined starches that leads to increased glycemic load and a strongly elevated omega-6/omega-3 ratio. For reference : The dietary omega-6/omega-3 ratio in hunter-gatherers is estimated to be around 1:1 to 3:1, whereas the ratio in the modern western diet is as high as 20:1 or more. This means that individuals who consume the standard American diet most likely have an endocannabinoid system that’s not functioning the way it should, resulting in a sluggish metabolism and weight gain. Diving a little bit deeper into the science: Omega-6 fatty acids are precursors to two very important endocannabinoids known as AEA and 2-AG. Both cannabinoids act via CB1 and CB2 receptors. CB1 receptors play a huge role in energy homeostasis, including appetite and metabolism. If you have an elevated dietary omega-6/omega-3 ratio, you end up with elevated levels of AEA and 2-AG – resulting in overstimulation of CB1 receptors which leads to increased appetite and metabolism dysfunction, and ultimately weight gain. As researchers note, weight gain is just one of many negative side effects: [Chronic overstimulation of CB1 receptors] contributes strongly to increased rates of obesity, unfavorable lipid profiles, insulin resistance, exacerbation of inflammation in the liver and kidneys, and increased cardiometabolic risk. Fortunately, marijuana cannabinoids can also interact with CB1 receptors. These particular receptors have a specific affinity for THC , the phytocannabinoid famous for its psychoactive effects – which is where our new theory kicks in. Marijuana Weight Loss Theory. Scientists with Cannabis and Cannabinoid Research have proposed a novel theory that cannabis use (and specifically THC) reverses the impact of the standard American diet by reducing the effects of an elevated ratio of omega-6/omega-3 fatty acids on endocannabinoid tone. The idea goes something like this: 1. The standard American diet contains a lot of sugars and refined starches that result in an elevated omega-6/omega-3 ratio. 2. Omega-6 fatty acids are converted into cannabinoids called AEA and 2-AG, which stimulate CB1 receptors. CB1 receptors play a huge role in regulating appetite and metabolism. 3. An elevated omega-6/omega-3 ratio results in more AEA and 2-AG, which leads to overstimulation of CB1 receptors – and increased appetite and metabolism dysfunction. 4. Cannabis, and specifically THC, down-regulates CB1 activity. Although marijuana causes an initial up-regulation (when users get the “munchies”), it quickly switches to influence longer lasting down-regulation behavior. But why is THC so important? Unlike other phytocannabinoids (such as CBD ), THC is able to bind directly with CB1 receptors – making it the main cannabinoid (we know of so far) that can get the job done. The proposed theory solves a lot of problems with previous research, as the study authors explain: This theory may explain inconsistencies among studies on the impact of cannabis use on metabolic dysregulation, as different populations have different diets. For example, epidemiological studies of the impact of cannabis use by cohorts of Swedish conscripts may reveal different results than epidemiological studies in the United States, due to different levels of obesity in the two countries. This logic also addresses the question of how medical marijuana and cannabis-based drugs like Marinol can increase appetite and weight gain in patients suffering from condition or treatment-related anorexia or wasting, but still increase weight loss in other patients. Stimulating CB1 receptors with THC results in up-regulation across the board (meaning most patients will experience an increase in appetite and calorie consumption). However, patients who need to gain weight likely have a much different omega-6/omega-3 ratio starting point than patients who need to lose weight; which means that as CB1 behavior switches to down-regulation, the balancing of these two fatty acids will result in different outcomes. Also, as patients go from barely eating at all to consuming more calories, weight gain may be reasonably expected opposed to situations where patients who routinely consume a healthy or excessive amount of calories experience a more efficient burning/storage of calories due to cannabis use. How to Use Marijuana to Lose Weight. So what does all this science mean for patients? How can you use medical marijuana to lose weight? In exploring marijuana’s role in weight loss, the present theory specifically highlights the importance of THC. As of right now, THC is considered the chief cannabinoid that directly binds with CB1 receptors. The biological behaviors and results described in this article are presently thought to be a specific consequence of THC consumption. As the study authors explain: Our theory suggests that the psychoactive effects of CB1 receptor stimulation with THC may be a necessary accompaniment to cannabis-induced weight loss, because down-regulation of CB1 receptors is required for reduced BMI, and it is not yet clear whether microdosing will cause down-regulation. However, weekly or biweekly cannabis use may be sufficient as significant decreases in BMI are observed at weekly usage rates. Researchers also point out: For many patients, cannabis may be a better option for weight loss than surgery or pharmaceuticals. However, patients with preexisting cardiovascular conditions or prior myocardial infractions should avoid cannabinoids or use them with caution. While the study authors don’t outline a weight loss “to do” list, they do make a number of predictions that – if their theory is true – could help guide weight loss efforts: Prediction 1: Chronic cannabis users may lose additional weight during periodic abstinence. BMI is reduced in cannabis users and, if the present theory is true, should decrease even more when users stop using cannabis because CB1 receptors remain down-regulated for several weeks following chronic cannabis consumption. Recently abstinent users would show reduced appetite and increased metabolic rates during this time. However, they will no longer experience short-term stimulation of appetite (the “munchies”), energy intake and storage, and reduced metabolic rates during each episode of acute cannabis consumption. Therefore, weight loss will increase as energy intake and storage remain depressed, and metabolism stimulated, until CB1 receptors return to pre-marijuana use levels. As researchers note, this prediction is well supported as weight loss during withdrawal from cannabis is one of the seven symptoms of “cannabis withdrawal” listed in the American Psychiatric Association ‘s manual, the DSM-V. Prediction 2: Different diets may lead to different results, depending on omega-6/omega-3 ratios. The impact of diet on the endocannabinoid system is predicted to vary as different populations consume different proportions of green vegetables, industrially produced animals, oceanic fishes, and processed foods. According to the current theory, populations with diets characterized by a high omega-6/omega-3 ratio (containing a lot of sugars and refined starches) will see significantly larger health improvements from cannabis use than those eating diets with more moderate ratios of omega-6/omega-3 fatty acids. Prediction 3: The combination of omega-3 supplements and cannabis could be a particularly effective treatment. According to scientists , reducing AEA and 2-AG synthesis with omega-3 supplements, and at the same time reducing CB1 receptor density with cannabis use, should reduce BMI and cardiometabolic risk factors more than either option alone. Importantly: [B]ecause CB1 receptors remain down-regulated for some time following use, weekly cannabis use may be sufficient to observe significant weight loss and metabolic benefits. The present theory predicts that omega-3 fatty acid supplements and cannabis use should exert a similar (though not identical) positive impact. CB1 Receptor Weight Loss Drugs. Not surprisingly, the pharmaceutical industry has already started exploring CB1 receptor drugs as potential weight loss weapons. In 2006, a medication called rimonabant – which acted as a selective CB1 antagonist/inverse agonist – was approved in 30 countries for the treatment of obesity. However, severe psychiatric side effects, including dizziness, anxiety, depression, and nausea, caused medication to be withdrawn several years later. Current studies suggest that peripherally restricted CB1 receptor antagonists may provide therapeutic benefits in obesity without the same psychiatric side effects. As researchers note: A therapeutic approach that acts both peripherally and centrally on the endocannabinoid system but does not cause severe psychiatric side effects is of great interest. Peripherally restricted CB1 receptor antagonists such as URB447 and AM6545 are showing promise… The Bottom Line. While the science above may seem overwhelming, the moral of the story is this: Researchers believe a marijuana compound called THC may correct an imbalance in our endocannabinoid system caused by the standard American diet (which contains a lot of sugar and refined starches), resulting in weight loss. While consuming marijuana may cause a short-term increase in appetite, it soon influences our body to switch gears and start burning and storing calories more efficiently. Patients may also notice a decrease in appetite. These effects may last weeks, which is why individuals may lose even more weight in the three to four weeks after they stop consuming cannabis (because the benefits are still in play, but the short-term spikes in appetite are missing). Weight loss results are believed to depend on the ratio of omega-6 and omega-3 fatty acids. While consuming cannabis appears to cancel out or decrease problems associated with having too much omega-6 in relation to omega-3, scientists suggest that adding omega-3 fatty acid supplements to cannabis treatment could provide an even greater boost. As researchers summarize: Dietary dysregulation of the endocannabinoid system is emerging as a primary cause of [many serious medical conditions]. Cannabis use in the United States appears to provide significant public health benefits due to partial or complete reversal of the metabolic dysregulation caused by the strongly elevated omega-6/omega-3 ratio of the American diet. The current meta-analysis provides strong evidence that cannabis use, and/or exposure to THC, results in reduced body mass index (BMI). While scientists race to explore and explain the more complex aspects of today’s topic (it’s important to keep in mind that the present theory is still a theory ), the most important takeaway is clear: Medical marijuana works. And it’s helping countless patients across the country lose weight as they embark upon healthier and happier lives. Getting Started with Medical Marijuana. Ready to try medical marijuana? Give CannaMD ‘s board certified physicians a call at (855) 420-9170 or complete a quick online form today! Our experienced team is always available to help! Find Out if You Qualify. You may be eligible for medical marijuana! Get Started. To stay up-to-date with the latest studies and legal regulations surrounding medical marijuana treatment, be sure to follow CannaMD on Facebook and sign up for our newsletter, below! Join 20K+ Subscribers! Get updates on more posts like this! Email *. This iframe contains the logic required to handle Ajax powered Gravity Forms. Basics Medical Conditions Obesity MORE
Microdosing Related Topics The Fresh Toast
FEBRUARY 11, 2020
Continue reading Why Patients Should Always Start With Microdosing Medical Marijuana at The Fresh Toast. Cannabis How-To Medical Marijuana RX microdosingFinding the right dose of a new medication can be tricky. The same is true of medical cannabis.
Leafly
MARCH 15, 2019
When it comes to microdosing, more than size matters. Arizona's Darwin Brands explain how their team customizes cannabis oil with microdosing in mind. The post Finding the Right Mix for Microdosing appeared first on Leafly. Strains & Products Darwin dosing edibles sponsored article vape pens
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Medicinal Marijuana Association
NOVEMBER 21, 2018
As more interest in CBD has led to more research, people have also begun wondering about the practice of microdosing. What is it, and how can it help medical marijuana patients? Cannabis Oil
Otherside Farms
JANUARY 16, 2019
Microdosing, if you have not yet heard of it, is hotter than just any ordinary trend: Science proves THC and CBD safe, with very real benefits associated with consuming very low doses regularly, as opposed to massive doses all at once. What is a Microdose? Purpose of Microdosing.
Miss Marijuana
DECEMBER 28, 2018
Microdosing cannabis allows users to experience the health benefits of marijuana without getting too high. What is microdosing? When talking about microdosing cannabis, the same principle applies. What does microdosing do? RELATED: A Handy Guide For Microdosing Weed.
Greencamp
FEBRUARY 14, 2019
Microdosing is a method of dosing cannabis in a way that allows you to reap its medical benefits without getting high. The other trend is a special approach to consuming cannabis, which was previously associated only with psychedelic substances—microdosing. Basics of microdosing.
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The Fresh Toast
SEPTEMBER 3, 2019
Doctors are embracing an emerging trend called microdosing, when the user to moderate their mind by taking small doses throughout the day. Continue reading Microdosing Marijuana: What Doctors Say Is The Best Way To Consume at The Fresh Toast. Cannabis Medical Marijuana microdosing
Leafly
FEBRUARY 19, 2019
The post Open Mike Eagle’s Creative Super Powers Fueled by Microdosing appeared first on Leafly. Hip hop artist, comedian, and cultural force Open Mike Eagle compares recording on Kiva cannabis edibles to eating Dragonball-Z’s senzu beans. Podcasts Music products strains The Hash
TOPS Cannabis
JULY 28, 2018
In recent years, microdosing has gained popularity in the cannabis community. Still, you may be wondering: What is microdosing? Microdosing is the act of using a very small amount of a substance to feel minor, but still perceptible, sensations. When it comes to microdosing cannabis, the idea is not to get high–– as counter-intuitive as that may sounds––but rather to get the point where you are just on the verge of being high. How To Microdose Cannabis.
Cannabis Law Report
FEBRUARY 14, 2020
The other trial will test LSD microdosing as an ADHD treatment. Mind Medicine, Inc. , a Canadian biotech firm, is entering Phase II clinical trials for two experimental treatments. According to its website, one trial involves an ibogaine-derived drug for treating opioid addiction. The company hasn’t yet generated revenue, but it’s anticipating a $50 million valuation when it goes public.
Cannabis Maven
APRIL 15, 2019
Microdosing is a technique that helps your body adjust to the doses you take by taking very small amounts periodically. Medical
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Cannabis Maven
APRIL 15, 2019
Microdosing is a technique that helps your body adjust to the doses you take by taking very small amounts periodically. Medical
Leafwell
JULY 10, 2018
Cannabis Dosing cannabinoids CBD dosing Edibles Effects of Marijuana microdosing side effects THCMedical marijuana, like any other medication, can have side-effects. Of course, side-effects such as being pain-free and being able to eat and sleep properly are positive ones.
Leafwell
JULY 3, 2018
Cannabis Dosing cannabis cooking CBD Oil cooking with marijuana dosing ingestion methods microdosingThere are many products with all sorts of ratios such as THC:CBD of 3:1, 1:20, 5:2 and so on.
Leafwell
JULY 17, 2017
Cannabis Dosing CBD dosing microdosing THCWe are moving into a new world of MMJ. No longer is it just flowers, hash and edibles of varying degrees of quality.
Leafly
FEBRUARY 18, 2020
What if you could microdose CBD all night long? The CBD Pillow turns this sweet dream into a reality. The post Is CBD microencapsulation the next secret to sleep? appeared first on Leafly. CBD cbd CBD Pillow sleep sponsored article
Leafwell
JANUARY 22, 2020
Cannabis Dosing cannabis cooking CBD Oil cooking with marijuana dosing ingestion methods microdosingThere are many products with all sorts of ratios such as THC:CBD of 3:1, 1:20, 5:2 and so on. Yet, when people try these ratios out, they sometimes find that two products, even with the same ratios, can have widely different effects, and sometimes even no effect.
Cannabis Life Network
JULY 6, 2019
Business Culture Featured Interview Latest Legalization News Law Marijuana News Science Dana Larsen Medicinal Mushroom Dispensary microdose psilocybes psilocybin war on drugs
Cannabis Law Report
JANUARY 1, 2020
Each gummy is 5 milligrams, a “very popular microdose for beginning edible consumers,” he said. Tweet 1 has already come in… @ LtGovStratton ? buys Mindy’s edibles at the 6 am opening of cannabis store in Wrigleyville. She pays with a $100 bill. CNN report.
The Marijuana Facts
JUNE 11, 2019
While microdosing THC and CBD is a relatively new trend on account of marijuanas growing popularity, there is some clinical research suggesting that less is in fact more when it comes to medicinal Cannabis. There is no optimal dose for microdosing with Cannabis.
Ellementa
JULY 1, 2018
” Stacie tried microdosing, taking smaller amounts of cannabis regularly throughout of the day to maintain a more balanced mood and eliminate her anxiety. Microdosing is individual to each person. “I microdose with edibles.
CannaTech
DECEMBER 15, 2019
When patients understand their disease state, how the endocannabinoid system interacts with all their other systems, comprehends the concept of microdosing, as well as the different components of different strains, and the many different methods of consumption available, we see amazing things.
Peninsula Alternative Health
DECEMBER 3, 2019
They are quick to tell you to microdose and to not just use cannabis as an end all be all but that a holistic approach to wellness is key to optimum health! We have another amazing month full of eventful memories! Obi from Melting Point Extracts always in an amazing mood and full of knowledge!
Miss Marijuana
JULY 5, 2019
Not a dose, but a microdose! “My My girlfriend is microdosing it every evening via a vaporizer and it helps her a lot falling and staying asleep. By: Madeleine Balestrier: Marijuana and sleep; what’s the deal? Sleep is the holy grail of adulthood. .
Canna Law Blog
JANUARY 22, 2020
It seems unlikely, even if microdosing continues to trend. Last week, COMPASS Pathways announced its acquisition of US Patent No 10,591,175. What does that patent cover? Psilocybin!
Peninsula Alternative Health
OCTOBER 17, 2019
Microdosing is Key. We want to remind patients that microdosing is important with vape pens.
Miss Marijuana
MARCH 11, 2019
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. I decided to try it anyways and I decided to microdose it. I use Durban Poison to microdose about every other day. By: Jessica N.
Miss Marijuana
JANUARY 5, 2019
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. RELATED: A Handy Guide For Microdosing Weed. By: Dee Dussault. The word “busy” has to go. We are all busy. We are all filled up with information and tasks.
Cannabis Law Report
SEPTEMBER 10, 2019
Dr. Garcia-Romeu Comments on Recent Study of Psychedelic Microdosing in Rats. Dr. Albert Garcia-Romeu commented on a recent study at UC Davis which found that microdoses of DMT could ease depression symptoms in rats.
Miss Marijuana
APRIL 6, 2019
RELATED: What Microdosing Cannabis Is Really Like, According To 14 Real People On Reddit. People have been using cannabis as medicine for years. Sadly, many have had to keep their use hidden due to outdated laws and misdirected societal norms.
Canna Newswire
MARCH 18, 2019
Right away, I thought to myself ‘that is the kind of guy who would make the ideal partner for a women-helmed and women-focused company,’ not to mention his microdosing product, Mom’s Formula, that is tailor-made for the women we serve.”.
CannaMD
OCTOBER 7, 2019
While medical marijuana has gained significant recognition over the past several years for its ability to safely and effectively treat a variety of conditions, ranging from anxiety and pain to cancer and Crohn’s disease , doctors have only recently started to notice a secondary – and equally intriguing – result of medical cannabis use: Weight loss. As leading researchers summarize: The effect size of cannabis use on body mass index (BMI) is large and the magnitude of the difference in BMI of users and non-users is of clinical significance. Besides going against all the classic “munchies/stoner” stereotypes, this finding is especially puzzling as cannabis is often used to increase weight gain in patients with medical conditions such as HIV/AIDS and cancer. So why are medical marijuana patients gaining weight when they need to, but losing weight when they don’t? How is a phenomenon like this even possible? And, if it’s true – as studies suggest – what can patients do to harness the weight loss power of medical cannabis to improve their overall health? CannaMD answers all these questions and more in today’s post! Already know that medical marijuana is right for you? Head on over to our appointment page to get started with medical cannabis today! Marijuana & Obesity Rates. The current trend of cannabis-related weight loss seems to fly in the face of classic “stoner” stereotypes. Don’t marijuana users consume more calories? How could people who eat more possibly weigh less? Are cannabis users really more likely to have better weight-to-height ratios than non-users? Believe it or not, science says: YES. Take the American Journal of Epidemiology. In 2011, researchers published cross-sectional data from two population-based surveys including over 50,000 respondents. Although obesity rates in the two surveys were 22.0% and 25.3% among participants reporting no use of cannabis in the past 12 months, obesity rates dropped to 14.3% and 17.2% among participants who reported using cannabis at least three days per week. Importantly, these differences were not accounted for by tobacco smoking status. As the study authors note: The proportion of obese participants decreased with the frequency of cannabis use. After adjusting for sex and age, cannabis use was also associated with body mass index (BMI) differences in both samples, leading researchers to conclude: …despite the evidence that cannabis use stimulates appetite in clinical trials and laboratory studies, cannabis users are actually less likely to be obese than nonusers in the general population. As counterintuitive as it might sound, this conclusion is actually in line with a growing number of studies. For instance, in a 2005 review of 297 medical charts, the Journal of Addictive Diseases reported that the rate of cannabis use in the last 12 months was lower in obese subjects than in subjects with a lower BMI. While investigators initially took these results as “support for overeating as competition for drugs and alcohol in brain reward sites,” follow-up studies suggest they might actually be pointing towards something else. But before we move on to why this pattern is happening, it’s important to establish that it is in fact a pattern. Fortunately, a recent flurry of new studies makes our job easy. After reviewing 3,617 participants, the American Journal of Cardiology reports: More extensive marijuana use was associated with a higher caloric intake… but not with higher body mass index (BMI) and lipid and glucose levels. Researchers with peer-reviewed journal, Obesity , drew similar conclusions. After analyzing data from 786 participants, investigators found: Cannabis use was statistically associated with lower body mass index (BMI) and lower percent fat mass… after adjusting for numerous confounding variables. Also of interest, The American Journal of Medicine adds: We found significant associations between marijuana use and smaller waist circumferences. Perhaps most impressive, a 2018 meta-analysis of 11 high-quality research studies observed among the reviewed reports: …significantly reduced body mass index (BMI) and rates of obesity in cannabis users, in conjunction with increased caloric intake. Now that we know marijuana-related weight loss is actually a real thing, we’re faced with an even bigger question: How does it work? While scientists are still searching for a definitive explanation, researchers with Cannabis and Cannabinoid Research have an interesting theory. What About the “Munchies”? Before exploring theory details, one important point deserves attention: Marijuana users eat more than non-marijuana users (and yet still weigh less). Almost every study cited above highlights increased caloric intake among marijuana users. One group of researchers found: [U]sers who had consumed cannabis for more than 1,800 days over 15 years consumed on average 619 more calories/day than nonusers, yet showed no difference in BMI. Likewise, in a study of 10,623 U.S. adults aged 29-50, Public Health Nutrition reports: We found caloric intake to be higher among marijuana users than among non-current users and that the intake increased as frequency of marijuana use increased. Although energy intake was higher among marijuana users, their body mass index (BMI) was somewhat lower. The same study also found that heavy users (subjects who reported using marijuana 11 or more times a month) consumed 582 more calories a day than non-users. Analyzing a collection of similar research, Cannabis and Cannabinoid Research summarizes: Across these studies, on average, cannabis users consumed an additional 834?calories/day relative to nonusers. As the BMI of cannabis users is lower than non-users, this suggests that marijuana users must have increased metabolic rates – which brings us to the next piece of our puzzle. Marijuana & Metabolism. In 2018, researchers set out to propose the first theoretical explanation for the cannabis calorie increase/weight loss paradox. And while the terms may sound complicated, the idea is actually quite simple. (To cut to the “bottom line,” scroll to the bottom of this post!). A number of important biological systems , including metabolism, depend on our endocannabinoid system. The endocannabinoid system is made up of receptors (the most studied are CB1 and CB2 ) and chemical compounds called cannabinoids. There are two types of cannabinoids: Endocannabinoids (the type your body naturally produces) and phytocannabinoids (the type produced by cannabis plants). And the coolest part? Both types share a number of key similarities. Meaning marijuana cannabinoids can interact with our natural endocannabinoid system to influence important biological systems, such as metabolism! Maintaining proper endocannabinoid system tone for optimal metabolic functioning requires a nice balance of omega-6 (linoleum acid, LA) and omega-3 (?-linolenic acid, ALA) fatty acids. To keep our body burning and storing calories the way it should, we need a good omega-6/omega-3 ratio. Unfortunately, the standard American diet is defined by a super-abundance of calories from sugars and refined starches that leads to increased glycemic load and a strongly elevated omega-6/omega-3 ratio. For reference : The dietary omega-6/omega-3 ratio in hunter-gatherers is estimated to be around 1:1 to 3:1, whereas the ratio in the modern western diet is as high as 20:1 or more. This means that individuals who consume the standard American diet most likely have an endocannabinoid system that’s not functioning the way it should, resulting in a sluggish metabolism and weight gain. Diving a little bit deeper into the science: Omega-6 fatty acids are precursors to two very important endocannabinoids known as AEA and 2-AG. Both cannabinoids act via CB1 and CB2 receptors. CB1 receptors play a huge role in energy homeostasis, including appetite and metabolism. If you have an elevated dietary omega-6/omega-3 ratio, you end up with elevated levels of AEA and 2-AG – resulting in overstimulation of CB1 receptors which leads to increased appetite and metabolism dysfunction, and ultimately weight gain. As researchers note, weight gain is just one of many negative side effects: [Chronic overstimulation of CB1 receptors] contributes strongly to increased rates of obesity, unfavorable lipid profiles, insulin resistance, exacerbation of inflammation in the liver and kidneys, and increased cardiometabolic risk. Fortunately, marijuana cannabinoids can also interact with CB1 receptors. These particular receptors have a specific affinity for THC , the phytocannabinoid famous for its psychoactive effects – which is where our new theory kicks in. Marijuana Weight Loss Theory. Scientists with Cannabis and Cannabinoid Research have proposed a novel theory that cannabis use (and specifically THC) reverses the impact of the standard American diet by reducing the effects of an elevated ratio of omega-6/omega-3 fatty acids on endocannabinoid tone. The idea goes something like this: 1. The standard American diet contains a lot of sugars and refined starches that result in an elevated omega-6/omega-3 ratio. 2. Omega-6 fatty acids are converted into cannabinoids called AEA and 2-AG, which stimulate CB1 receptors. CB1 receptors play a huge role in regulating appetite and metabolism. 3. An elevated omega-6/omega-3 ratio results in more AEA and 2-AG, which leads to overstimulation of CB1 receptors – and increased appetite and metabolism dysfunction. 4. Cannabis, and specifically THC, down-regulates CB1 activity. Although marijuana causes an initial up-regulation (when users get the “munchies”), it quickly switches to influence longer lasting down-regulation behavior. But why is THC so important? Unlike other phytocannabinoids (such as CBD ), THC is able to bind directly with CB1 receptors – making it the main cannabinoid (we know of so far) that can get the job done. The proposed theory solves a lot of problems with previous research, as the study authors explain: This theory may explain inconsistencies among studies on the impact of cannabis use on metabolic dysregulation, as different populations have different diets. For example, epidemiological studies of the impact of cannabis use by cohorts of Swedish conscripts may reveal different results than epidemiological studies in the United States, due to different levels of obesity in the two countries. This logic also addresses the question of how medical marijuana and cannabis-based drugs like Marinol can increase appetite and weight gain in patients suffering from condition or treatment-related anorexia or wasting, but still increase weight loss in other patients. Stimulating CB1 receptors with THC results in up-regulation across the board (meaning most patients will experience an increase in appetite and calorie consumption). However, patients who need to gain weight likely have a much different omega-6/omega-3 ratio starting point than patients who need to lose weight; which means that as CB1 behavior switches to down-regulation, the balancing of these two fatty acids will result in different outcomes. Also, as patients go from barely eating at all to consuming more calories, weight gain may be reasonably expected opposed to situations where patients who routinely consume a healthy or excessive amount of calories experience a more efficient burning/storage of calories due to cannabis use. How to Use Marijuana to Lose Weight. So what does all this science mean for patients? How can you use medical marijuana to lose weight? In exploring marijuana’s role in weight loss, the present theory specifically highlights the importance of THC. As of right now, THC is considered the chief cannabinoid that directly binds with CB1 receptors. The biological behaviors and results described in this article are presently thought to be a specific consequence of THC consumption. As the study authors explain: Our theory suggests that the psychoactive effects of CB1 receptor stimulation with THC may be a necessary accompaniment to cannabis-induced weight loss, because down-regulation of CB1 receptors is required for reduced BMI, and it is not yet clear whether microdosing will cause down-regulation. However, weekly or biweekly cannabis use may be sufficient as significant decreases in BMI are observed at weekly usage rates. Researchers also point out: For many patients, cannabis may be a better option for weight loss than surgery or pharmaceuticals. However, patients with preexisting cardiovascular conditions or prior myocardial infractions should avoid cannabinoids or use them with caution. While the study authors don’t outline a weight loss “to do” list, they do make a number of predictions that – if their theory is true – could help guide weight loss efforts: Prediction 1: Chronic cannabis users may lose additional weight during periodic abstinence. BMI is reduced in cannabis users and, if the present theory is true, should decrease even more when users stop using cannabis because CB1 receptors remain down-regulated for several weeks following chronic cannabis consumption. Recently abstinent users would show reduced appetite and increased metabolic rates during this time. However, they will no longer experience short-term stimulation of appetite (the “munchies”), energy intake and storage, and reduced metabolic rates during each episode of acute cannabis consumption. Therefore, weight loss will increase as energy intake and storage remain depressed, and metabolism stimulated, until CB1 receptors return to pre-marijuana use levels. As researchers note, this prediction is well supported as weight loss during withdrawal from cannabis is one of the seven symptoms of “cannabis withdrawal” listed in the American Psychiatric Association ‘s manual, the DSM-V. Prediction 2: Different diets may lead to different results, depending on omega-6/omega-3 ratios. The impact of diet on the endocannabinoid system is predicted to vary as different populations consume different proportions of green vegetables, industrially produced animals, oceanic fishes, and processed foods. According to the current theory, populations with diets characterized by a high omega-6/omega-3 ratio (containing a lot of sugars and refined starches) will see significantly larger health improvements from cannabis use than those eating diets with more moderate ratios of omega-6/omega-3 fatty acids. Prediction 3: The combination of omega-3 supplements and cannabis could be a particularly effective treatment. According to scientists , reducing AEA and 2-AG synthesis with omega-3 supplements, and at the same time reducing CB1 receptor density with cannabis use, should reduce BMI and cardiometabolic risk factors more than either option alone. Importantly: [B]ecause CB1 receptors remain down-regulated for some time following use, weekly cannabis use may be sufficient to observe significant weight loss and metabolic benefits. The present theory predicts that omega-3 fatty acid supplements and cannabis use should exert a similar (though not identical) positive impact. CB1 Receptor Weight Loss Drugs. Not surprisingly, the pharmaceutical industry has already started exploring CB1 receptor drugs as potential weight loss weapons. In 2006, a medication called rimonabant – which acted as a selective CB1 antagonist/inverse agonist – was approved in 30 countries for the treatment of obesity. However, severe psychiatric side effects, including dizziness, anxiety, depression, and nausea, caused medication to be withdrawn several years later. Current studies suggest that peripherally restricted CB1 receptor antagonists may provide therapeutic benefits in obesity without the same psychiatric side effects. As researchers note: A therapeutic approach that acts both peripherally and centrally on the endocannabinoid system but does not cause severe psychiatric side effects is of great interest. Peripherally restricted CB1 receptor antagonists such as URB447 and AM6545 are showing promise… The Bottom Line. While the science above may seem overwhelming, the moral of the story is this: Researchers believe a marijuana compound called THC may correct an imbalance in our endocannabinoid system caused by the standard American diet (which contains a lot of sugar and refined starches), resulting in weight loss. While consuming marijuana may cause a short-term increase in appetite, it soon influences our body to switch gears and start burning and storing calories more efficiently. Patients may also notice a decrease in appetite. These effects may last weeks, which is why individuals may lose even more weight in the three to four weeks after they stop consuming cannabis (because the benefits are still in play, but the short-term spikes in appetite are missing). Weight loss results are believed to depend on the ratio of omega-6 and omega-3 fatty acids. While consuming cannabis appears to cancel out or decrease problems associated with having too much omega-6 in relation to omega-3, scientists suggest that adding omega-3 fatty acid supplements to cannabis treatment could provide an even greater boost. As researchers summarize: Dietary dysregulation of the endocannabinoid system is emerging as a primary cause of [many serious medical conditions]. Cannabis use in the United States appears to provide significant public health benefits due to partial or complete reversal of the metabolic dysregulation caused by the strongly elevated omega-6/omega-3 ratio of the American diet. The current meta-analysis provides strong evidence that cannabis use, and/or exposure to THC, results in reduced body mass index (BMI). While scientists race to explore and explain the more complex aspects of today’s topic (it’s important to keep in mind that the present theory is still a theory ), the most important takeaway is clear: Medical marijuana works. And it’s helping countless patients across the country lose weight as they embark upon healthier and happier lives. Getting Started with Medical Marijuana. Ready to try medical marijuana? Give CannaMD ‘s board certified physicians a call at (855) 420-9170 or complete a quick online form today! Our experienced team is always available to help! Find Out if You Qualify. You may be eligible for medical marijuana! Get Started. To stay up-to-date with the latest studies and legal regulations surrounding medical marijuana treatment, be sure to follow CannaMD on Facebook and sign up for our newsletter, below! Join 20K+ Subscribers! Get updates on more posts like this! Email *. This iframe contains the logic required to handle Ajax powered Gravity Forms. Basics Medical Conditions Obesity
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