The Cannigma

JUNE 28, 2025

It’s a day that commemorates the fight against oppression and the pursuit of self-determination. At first glance, these two days may appear worlds apart, representing distinct traditions and causes. This historic act enshrined the principles of liberty, self-governance, and personal autonomy, laying the foundation for a new nation.

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Education Medicine Hemp History 59

LifeCannMD

APRIL 18, 2025

This is a great opportunity for someone who enjoys connecting with others, thrives in a supportive environment, and wants to grow within the wellness industry. Please send your resume and cover letter to: monika@lifecannmd.com Dr. Sende Wellness | LifeCannMD 1063 SW 8th St, Miami, FL 33130 T: 833-543-3226 Lets make a differencetogether.

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Environment Data Patients Marijuana 52

Kind Meds (Cannabis Education Blog)

JULY 3, 2025

Nestled in Mesa, Arizona, we’ve been here since the early medical-only days, serving the local community with quality cannabis, knowledgeable staff, and a commitment to care that hasn’t changed. In an industry full of pop-ups and out-of-state takeovers, Kind Meds remains a true Arizona OG. Want to know how it all began? No filler products.

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Dispensary Concentrates Education Edibles 52

Veriheal

JUNE 12, 2025

In January, the US Food and Drug Administration (FDA) approved the Johnson & Johnson brand nasal spray, Spravato®, as the world’s first and only monotherapy for addressing treatment-resistant cases of major depressive disorder (MDD). What’s in the ketamine-derived nasal spray, and how do people use it?

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Therapy Treatment Clinical Trials Blood Pressure 69

TheAnswerPage

MAY 13, 2021

See Answer. See Answer. Learn something every day ® right from your inbox. Sign up for The Answer of the Day email…. Sign up for The Answer of the Day email…. What are the common modes of administration of medical marijuana used by cancer patients? Deepti Behl, Stacy D. Sign Up!

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Tincture Vaping Topical Edibles 66

TheAnswerPage

JUNE 4, 2022

See the Answer. What is the half life of CBD? How does it compare to the half life of THC? The half life of CBD is 18-32 hours, which is similar to the half life of THC of 20-30 hours. Both CBD and THC are distributed to fatty tissues and highly perfused organs such as brain, heart, lung, and liver. Page II , Larry A. Allen , Robert A.

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THC CBD Recreational Marijuana 89

TheAnswerPage

JUNE 2, 2022

See the Answer. Are cannabinoid receptors present in pain transmission circuits? Cannabinoid receptors are present in multiple areas of the pain transmission circuitry. CB receptors are present on peripheral sensory nerve endings as well as the spinal cord and supraspinal regions in the brain. Current Psychiatry. Leo Raymond M.

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Cannabinoids 81

TheAnswerPage

JUNE 20, 2022

See the Answer. How does the endocannabinoid system impart analgesic effects? The endocannabinoid system inhibits release of presynaptic neurotransmitters, modifies postsynaptic neuronal excitability, activates descending inhibitory pathways, and reduces neuroinflammation. Chung M, Kim H, Abdi S. Current Opinion in Anesthesiology.

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Cannabinoids Cannabis 81

TheAnswerPage

JUNE 6, 2022

See the Answer. What are some of the more common reasons dermatologists recommend cannabinoid-based medicines? According to the results of a survey of 145 dermatologists, 91 % of dermatologists were in support of medical cannabis use and 13.8 % have recommended it for a dermatologic condition.

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Topical Conditions Cannabinoids Medicine 75

TheAnswerPage

JULY 1, 2022

See the Answer. On June 21, 2022, Purdue Pharma announced that Nalmefene HCl Injection, 2mg/2mL (1mg/1mL) is now available in the U.S. For what condition is Nalmefene HCl indicated? According to the press release, Purdue Pharma will distribute injectable nalmefene for no profit as part of its commitment to help abate the opioid crisis.

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Treatment Conditions Cannabis 75

TheAnswerPage

JUNE 15, 2022

See the Answer. Cannabinoid receptors are located throughout various parts of the CNS, including the basal ganglia, hippocampus, cerebellum and cerebral cortex, and in the peripheral nervous system. Do these receptors have effects on neurotransmitters such as serotonin? Levinsohn, Kevin P. Journal of the Neurological Sciences. Winterstein.

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Cannabinoids Events Medicine CBD 75

TheAnswerPage

JUNE 18, 2022

See the Answer. Has the terpenoid caryophyllene, which is found in the cannabis plant, been found to significantly reduce cravings for cigarettes? Yes, according to one study with significant findings (P. Rose JE, Behm FM. Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. Drug Alcohol Depend. PMID: 8033760.

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Extraction Cannabis 75

TheAnswerPage

MAY 22, 2022

See the Answer. The FDA has issued a document with full prescribing information for a CBD product, Epidiolex. According to this document, are there any blood tests that should be performed prior to initiating treatment with Epidiolex? Highlights for prescribing information for Epidiolex [link].

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Treatment Patients CBD 75

TheAnswerPage

AUGUST 23, 2022

See the Answer. A June 2022 research study conducted in Ontario Canada (where cannabis-based medicine is legal at the federal level), assessed how chronic pain patients view the use of cannabis-based products for medicinal purposes. Do you think that most patients viewed cannabinoid-based therapeutics as an effective pain remedy?

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Chronic Pain Medicine Collective Data 75

TheAnswerPage

JULY 7, 2022

See the Answer. What percentage used cannabis-based products as a substitute? “Overall, 47.1% (n = 1269) of participants reported substituting cannabis for pharmaceuticals or other substances (e.g., alcohol, tobacco/nicotine). Older, female participants had higher odds of disclosing cannabis substitution to their PCPs.”

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Pharmaceutical Patients Cannabis 75

Cannabis Cheri

MARCH 25, 2021

The results showed the study’s participants exhibited no evidence of liver toxicity after using CBD daily for a minimum of 60 days. Care by Design Hemp , a wholly-owned CannaCraft brand, is pleased to announce that the groundbreaking clinical study exploring the effects of CBD on liver health has concluded after seven months of research.

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CBD Data Safety Tincture 235

NORML

MAY 12, 2020

Once her teaching career had ended, Tamara was forced to answer the question of who she was now in this world. Tamara Netzel was a middle school English teacher, an Army officer’s wife, and possibly the most cannabis naive individual you could have met. It concerned her that even as a registered patient, she could still be arrested.

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Advocacy Legislation Chronic Pain Education 316

TheAnswerPage

MAY 2, 2023

The results of in vitro studies suggest that typical CBD doses of 300 mg to 1,500 mg per day may result in a greater than 50% inhibition of CYP2C19, and thus less of the active metabolite is created and the anti-paltlet activity may be decreased. See the Answer Does CBD interact with the anti-platlet agent Plavix (Clopidogrel)?

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Events Cannabinoids CBD 45

TheAnswerPage

APRIL 15, 2023

doi: [link] “>[link] See the Answer The Journal of the American Osteopathic Association, February 2018, Vol. doi: [link] “>[link] See the Answer Hashish is a crude product made up of compacted sticky resin glands of the cannabis plant. Special Report | February 2018. Jeramy Peters, DO; Joseph Chien, DO.

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Concentrates Consumption Cannabis 61

TheAnswerPage

AUGUST 7, 2021

See the Answer. Some patients apply CBD topically. Does CBD easily penetrate the skin? Due to CBD’s large size and hydrophobic properties, CBD does not penetrate the skin efficiently, however, permeation-enhancing gels have been developed.

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Epilepsy Topical Treatment CBD 61

TheAnswerPage

APRIL 13, 2021

See Answer. See Answer. What is the endocannabinoid system? The endocannabinoid system (ECS) is an internal homeostatic system present in all vertebrates that plays a critical role in the nervous system and regulates multiple physiological processes, including appetite, digestion, mood, coordination, and other processes. Di Marzo V.

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Digestion Research and Development 61

NORML

FEBRUARY 5, 2019

“There are several meetings made for constituents to meet with their legislators on both days. The forum includes an educational seminar on cannabis, a review of House Bill 136 (HB136) and an expert question and answer session. 5 with constituents from across the state seeking cannabis reform. 9 during a news conference.

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Cannabis Cheri

JANUARY 18, 2019

This fact continually frustrates budding cannabis cooks (pun intended) who want an easy answer. If not, wait until the next day and try eating a dose that’s 5 or 10 mgs. Continue increasing day after day until you find a dosage amount that makes you feel good. We hear a lot about cannabis edibles dosages. per serving).

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Edibles Marijuana THC Media 193

TheAnswerPage

JULY 17, 2022

See the Answer. Are CBD-rich extracts more effective at reducing seizures compared to purified CBD products? In 2017, researchers performed an analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products. Pamplona F, da Silva L and Coan A. 12 September 2018. Sec.Neuropharmacology.

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Epilepsy Extraction Treatment CBD 56

TheAnswerPage

MAY 15, 2022

See the Answer. Is CBD addictive? According to the drug package insert of an FDA-approved CBD product, CBD is not addictive. GW Pharmaceuticals press release: “GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich Biosciences, Inc. link] Accessed April 30, 2020. [link] Accessed April 30, 2020. GW Pharmaceuticals website.

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Pharmaceutical Packaging CBD Access 56

TheAnswerPage

APRIL 24, 2022

See the Answer. What is the MORE Act? If passed, “The Marijuana Opportunity Reinvestment and Expungement Act, also known as the MORE Act, would remove marijuana from the controlled substances list, leaving it up to states to set their own laws. ” ABC News: House set to pass legislation decriminalizing marijuana.

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Decriminalization Legislation Marijuana Law 56

TheAnswerPage

JANUARY 10, 2022

See the Answer. Are blunts and joints the same thing? Blunts and joints are not the same. Blunts consist of marijuana wrapped in tobacco leaves, whereas joints consist of marijuana wrapped in cigarette paper. Cooper ZD, Haney M. Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts.

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Marijuana 56

Cannabis Cheri

JANUARY 29, 2019

Like everything associated with cannabis dosing, both THC and CBD, there simply is no one answer to that question that works for everyone. And being a “beginner” has little to do with it. Cannabis is bi-phasic, meaning that large doses and small doses can sometimes create completely opposite effects! Let’s Explore.

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CBD THC Edibles Conditions 172

The Cannigma

MARCH 10, 2022

Getting the right answers in your cannabis journey can be tricky. But with The Cannigma’s Ask the Expert, you can find questions from readers like you, answered by a real cannabis pharmacist. Answer: Heidi, Thanks for your question and for reading The Canngima. Have a burning cannabis question you need answered?

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Topical Oil Cannabinoids Hemp 98

TheAnswerPage

MAY 16, 2023

82(12): 1083-1092. [link] See the Answer The cannabinoids act on the presynaptic CB1 receptors, and the receptor activation reduces massive glutamate release and regulates glutamatergic excitability during spasticity. Neurology 2014.

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Cannabinoids Extraction Treatment Medicine 45

TheAnswerPage

MAY 15, 2023

2001; 56: 1059-1068. [link] See the Answer Kumar RN, Chambers WA, Pertwee RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia.

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Chronic Pain Sleep Cannabinoids Marijuana 45

TheAnswerPage

MAY 13, 2023

10.3390/toxins13020117 [link] See the Answer True or False? CB1 receptors are only found on nerve cells. Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins (Basel). 2021 Feb 5;13(2):117.

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Cannabis 45

TheAnswerPage

MAY 12, 2023

link] [link] See the Answer True or false? The FDA has approved a CBD product derived from marijuana (not hemp). The FDA has approved Epidiolex (cannabidiol).

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Treatment CBD Hemp Marijuana 45

TheAnswerPage

MAY 11, 2023

297A (Definitions) (2018). [link] See the Answer What is hemp? Hemp is a genetic variant of Cannabis sativa, which has been bred to maximize its fiber content and minimize its phytocannabinoid content, especially of THC. The concentration of THC in hemp is not more than 0.3 percent on a dry weight basis.

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Sativa Agriculture Concentrates Hemp 45

TheAnswerPage

MAY 5, 2023

2001; 134(12):1159-1162 [link] See the Answer Ann Intern Med.2001; 2001; 134(12):1159-1162 [link] See the Answer Are cannabis and marijuana the same thing? Actually, no. Medical Marijuana: the continuing story. Ann Intern Med.2001;

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Sativa Extraction Marijuana Cannabis 45

TheAnswerPage

MAY 3, 2023

See the Answer Does digoxin interact with cannabinoids? Some cannabinoids may affect the metabolic activity of P-glycoprotein (P-gp). CBD, for example, may inhibit P-gp, and potentially increase digoxin levels. Some patients who consume both digoxin and CBD may need to reduce their digoxin dose to maintain safe therapeutic levels of digoxin.

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Cannabinoids CBD Patients 45

TheAnswerPage

APRIL 23, 2023

The Journal of Toxicological Sciences, 40(6), 797–803. [link] See the Answer Some people consume cannabinoids via “dabbing.” ” Describe this method of consumption. Basically, with dabbing, a cannabis concentrate is applied to a hot platform and the cannabinoids are volatilized. Elzinga, S., & Kaplan, C.

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