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See Answer. See Answer. Learn something every day ® right from your inbox. Sign up for The Answer of the Day email…. Sign up for The Answer of the Day email…. What are the common modes of administration of medical marijuana used by cancer patients? Deepti Behl, Stacy D. Sign Up!
See the Answer. What is the half life of CBD? How does it compare to the half life of THC? The half life of CBD is 18-32 hours, which is similar to the half life of THC of 20-30 hours. Both CBD and THC are distributed to fatty tissues and highly perfused organs such as brain, heart, lung, and liver. Page II , Larry A. Allen , Robert A.
See the Answer. Are cannabinoid receptors present in pain transmission circuits? Cannabinoid receptors are present in multiple areas of the pain transmission circuitry. CB receptors are present on peripheral sensory nerve endings as well as the spinal cord and supraspinal regions in the brain. Current Psychiatry. Leo Raymond M.
See the Answer. How does the endocannabinoid system impart analgesic effects? The endocannabinoid system inhibits release of presynaptic neurotransmitters, modifies postsynaptic neuronal excitability, activates descending inhibitory pathways, and reduces neuroinflammation. Chung M, Kim H, Abdi S. Current Opinion in Anesthesiology.
See the Answer. What are some of the more common reasons dermatologists recommend cannabinoid-based medicines? According to the results of a survey of 145 dermatologists, 91 % of dermatologists were in support of medical cannabis use and 13.8 % have recommended it for a dermatologic condition.
See the Answer. On June 21, 2022, Purdue Pharma announced that Nalmefene HCl Injection, 2mg/2mL (1mg/1mL) is now available in the U.S. For what condition is Nalmefene HCl indicated? According to the press release, Purdue Pharma will distribute injectable nalmefene for no profit as part of its commitment to help abate the opioid crisis.
See the Answer. Cannabinoid receptors are located throughout various parts of the CNS, including the basal ganglia, hippocampus, cerebellum and cerebral cortex, and in the peripheral nervous system. Do these receptors have effects on neurotransmitters such as serotonin? Levinsohn, Kevin P. Journal of the Neurological Sciences. Winterstein.
See the Answer. Has the terpenoid caryophyllene, which is found in the cannabis plant, been found to significantly reduce cravings for cigarettes? Yes, according to one study with significant findings (P. Rose JE, Behm FM. Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. Drug Alcohol Depend. PMID: 8033760.
See the Answer. The FDA has issued a document with full prescribing information for a CBD product, Epidiolex. According to this document, are there any blood tests that should be performed prior to initiating treatment with Epidiolex? Highlights for prescribing information for Epidiolex [link].
See the Answer. A June 2022 research study conducted in Ontario Canada (where cannabis-based medicine is legal at the federal level), assessed how chronic pain patients view the use of cannabis-based products for medicinal purposes. Do you think that most patients viewed cannabinoid-based therapeutics as an effective pain remedy?
See the Answer. What percentage used cannabis-based products as a substitute? “Overall, 47.1% (n = 1269) of participants reported substituting cannabis for pharmaceuticals or other substances (e.g., alcohol, tobacco/nicotine). Older, female participants had higher odds of disclosing cannabis substitution to their PCPs.”
The results showed the study’s participants exhibited no evidence of liver toxicity after using CBD daily for a minimum of 60 days. Care by Design Hemp , a wholly-owned CannaCraft brand, is pleased to announce that the groundbreaking clinical study exploring the effects of CBD on liver health has concluded after seven months of research.
Once her teaching career had ended, Tamara was forced to answer the question of who she was now in this world. Tamara Netzel was a middle school English teacher, an Army officer’s wife, and possibly the most cannabis naive individual you could have met. It concerned her that even as a registered patient, she could still be arrested.
The results of in vitro studies suggest that typical CBD doses of 300 mg to 1,500 mg per day may result in a greater than 50% inhibition of CYP2C19, and thus less of the active metabolite is created and the anti-paltlet activity may be decreased. See the Answer Does CBD interact with the anti-platlet agent Plavix (Clopidogrel)?
See Answer. See Answer. Are cannabis and marijuana the same thing? Actually, no. Cannabis is a flowering plant, while marijuana is defined as a substance composed of parts of the Cannabis sativa plant, including the leaves, flowers, seeds, and the resin extracted from any part of the plant. Medical Marijuana: the continuing story.
“There are several meetings made for constituents to meet with their legislators on both days. The forum includes an educational seminar on cannabis, a review of House Bill 136 (HB136) and an expert question and answer session. 5 with constituents from across the state seeking cannabis reform. 9 during a news conference.
Imagine living with thata constant noise that never stops, day or night. But when you’re suffering every day, you’ll try almost anything, won’t you? During his desperate search for answers, Rick discovered something that would change everything. This story is messy, controversial, and deeply human.
doi: [link] “>[link] See the Answer The Journal of the American Osteopathic Association, February 2018, Vol. doi: [link] “>[link] See the Answer Hashish is a crude product made up of compacted sticky resin glands of the cannabis plant. Special Report | February 2018. Jeramy Peters, DO; Joseph Chien, DO.
See the Answer. Some patients apply CBD topically. Does CBD easily penetrate the skin? Due to CBD’s large size and hydrophobic properties, CBD does not penetrate the skin efficiently, however, permeation-enhancing gels have been developed.
See Answer. See Answer. What is the endocannabinoid system? The endocannabinoid system (ECS) is an internal homeostatic system present in all vertebrates that plays a critical role in the nervous system and regulates multiple physiological processes, including appetite, digestion, mood, coordination, and other processes. Di Marzo V.
I get variations on these questions all the time and my answer is always the same: I have no idea. I know this is not the simple one-size-fits-all answer everyone wants to hear, but I always want to tell you the truth. Dear Cheri, How much marijuana to a stick of butter? . How much marijuana should I use for a cup of oil? .
This fact continually frustrates budding cannabis cooks (pun intended) who want an easy answer. If not, wait until the next day and try eating a dose that’s 5 or 10 mgs. Continue increasing day after day until you find a dosage amount that makes you feel good. We hear a lot about cannabis edibles dosages. per serving).
See the Answer. Are CBD-rich extracts more effective at reducing seizures compared to purified CBD products? In 2017, researchers performed an analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products. Pamplona F, da Silva L and Coan A. 12 September 2018. Sec.Neuropharmacology.
See the Answer. Is CBD addictive? According to the drug package insert of an FDA-approved CBD product, CBD is not addictive. GW Pharmaceuticals press release: “GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich Biosciences, Inc. link] Accessed April 30, 2020. [link] Accessed April 30, 2020. GW Pharmaceuticals website.
See the Answer. What is the MORE Act? If passed, “The Marijuana Opportunity Reinvestment and Expungement Act, also known as the MORE Act, would remove marijuana from the controlled substances list, leaving it up to states to set their own laws. ” ABC News: House set to pass legislation decriminalizing marijuana.
See the Answer. Are blunts and joints the same thing? Blunts and joints are not the same. Blunts consist of marijuana wrapped in tobacco leaves, whereas joints consist of marijuana wrapped in cigarette paper. Cooper ZD, Haney M. Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts.
Like everything associated with cannabis dosing, both THC and CBD, there simply is no one answer to that question that works for everyone. And being a “beginner” has little to do with it. Cannabis is bi-phasic, meaning that large doses and small doses can sometimes create completely opposite effects! Let’s Explore.
This is a great opportunity for someone who enjoys connecting with others, thrives in a supportive environment, and wants to grow within the wellness industry. Please send your resume and cover letter to: monika@lifecannmd.com Dr. Sende Wellness | LifeCannMD 1063 SW 8th St, Miami, FL 33130 T: 833-543-3226 Lets make a differencetogether.
82(12): 1083-1092. [link] See the Answer The cannabinoids act on the presynaptic CB1 receptors, and the receptor activation reduces massive glutamate release and regulates glutamatergic excitability during spasticity. Neurology 2014.
2001; 56: 1059-1068. [link] See the Answer Kumar RN, Chambers WA, Pertwee RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia.
10.3390/toxins13020117 [link] See the Answer True or False? CB1 receptors are only found on nerve cells. Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins (Basel). 2021 Feb 5;13(2):117.
link] [link] See the Answer True or false? The FDA has approved a CBD product derived from marijuana (not hemp). The FDA has approved Epidiolex (cannabidiol).
297A (Definitions) (2018). [link] See the Answer What is hemp? Hemp is a genetic variant of Cannabis sativa, which has been bred to maximize its fiber content and minimize its phytocannabinoid content, especially of THC. The concentration of THC in hemp is not more than 0.3 percent on a dry weight basis.
2001; 134(12):1159-1162 [link] See the Answer Ann Intern Med.2001; 2001; 134(12):1159-1162 [link] See the Answer Are cannabis and marijuana the same thing? Actually, no. Medical Marijuana: the continuing story. Ann Intern Med.2001;
See the Answer Does digoxin interact with cannabinoids? Some cannabinoids may affect the metabolic activity of P-glycoprotein (P-gp). CBD, for example, may inhibit P-gp, and potentially increase digoxin levels. Some patients who consume both digoxin and CBD may need to reduce their digoxin dose to maintain safe therapeutic levels of digoxin.
The Journal of Toxicological Sciences, 40(6), 797–803. [link] See the Answer Some people consume cannabinoids via “dabbing.” ” Describe this method of consumption. Basically, with dabbing, a cannabis concentrate is applied to a hot platform and the cannabinoids are volatilized. Elzinga, S., & Kaplan, C.
link] “>[link] See the Answer The labels of some probiotic supplements indicate that probiotics support a healthy immune system, strengthen digestive balance, help maintain a balance of healthy intestinal bacteria, help break down undigested carbohydrates and sugars, and facilitate the absorption of nutrients.
Molecules 2021, 26, 802. [link] See the Answer Cannabinoid receptors are present on many types of skin cells, including keratinocytes and fibroblasts. Analyses also showed that hydrogels based on cannabis extracts have a positive effect on skin hydration. Zagórska-Dziok,M.; Ziemlewska, A.; Nizioł-Łukaszewska, Z.
Aug 30, 2021 [link] See the Answer Cannabinoid type 2 receptors, like type 1 receptors, are G-protein coupled receptors; the type 2 receptors are primarily on the surface of the immune system cells, tonsils, the gi tract, bone, and peripheral nerve endings. Lundholm, M., Emanuele, N. Rev Endocr Metab Disord (2021).
Aug 30, 2021 [link] See the Answer They mediate agonist as well as antagonist effects via cannabinoid receptors found in the brain and peripheral nervous system. Lundholm, M., Emanuele, N. The effects of cannabis and cannabinoids on the endocrine system. Rev Endocr Metab Disord (2021).
Getting the right answers in your cannabis journey can be tricky. But with The Cannigma’s Ask the Expert, you can find questions from readers like you, answered by a real cannabis pharmacist. Answer: Heidi, Thanks for your question and for reading The Canngima. Have a burning cannabis question you need answered?
Getting the right answers in your cannabis journey can be tricky. But with The Cannigma’s Ask the Expert, you can find questions from readers like you, answered by a real cannabis pharmacist. Answer: Dear Lynn, Thank you for your question. Have a burning cannabis question you need answered? Best of luck!
Presented by Business of Cannabis and Torkin Manes LLP, this day-long event will explore the challenges and opportunities for the cannabis sector on the other side of COVID-19. We will hear from industry experts about their answers to the question: What’s Next? We apply our entirely subjective bong score to each event.
Today she takes a 10-20mg THC edible before she goes to sleep to help her get the rest she needs, as well as micro doses of 1.25mg THC during the day. We know that with Fibromyalgia the sleep disruption causes a lot of the problems during the day. Sometimes, where you’re meant to be is 180 degrees from where you started out.
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