TheAnswerPage

JUNE 4, 2022

What is the half life of CBD? How does it compare to the half life of THC? The half life of CBD is 18-32 hours, which is similar to the half life of THC of 20-30 hours. Both CBD and THC are distributed to fatty tissues and highly perfused organs such as brain, heart, lung, and liver.

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TheAnswerPage

JUNE 2, 2022

Are cannabinoid receptors present in pain transmission circuits? Cannabinoid receptors are present in multiple areas of the pain transmission circuitry. CB receptors are present on peripheral sensory nerve endings as well as the spinal cord and supraspinal regions in the brain. Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121,

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Cannabinoids 81

TheAnswerPage

JUNE 20, 2022

How does the endocannabinoid system impart analgesic effects? The endocannabinoid system inhibits release of presynaptic neurotransmitters, modifies postsynaptic neuronal excitability, activates descending inhibitory pathways, and reduces neuroinflammation. Chung M, Kim H, Abdi S. Update on cannabis and cannabinoids for cancer pain.

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Cannabinoids Cannabis 81

TheAnswerPage

JUNE 6, 2022

What are some of the more common reasons dermatologists recommend cannabinoid-based medicines? According to the results of a survey of 145 dermatologists, 91 % of dermatologists were in support of medical cannabis use and 13.8 % have recommended it for a dermatologic condition.

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TheAnswerPage

JULY 1, 2022

On June 21, 2022, Purdue Pharma announced that Nalmefene HCl Injection, 2mg/2mL (1mg/1mL) is now available in the U.S. For what condition is Nalmefene HCl indicated?

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TheAnswerPage

JUNE 15, 2022

Cannabinoid receptors are located throughout various parts of the CNS, including the basal ganglia, hippocampus, cerebellum and cerebral cortex, and in the peripheral nervous system. Do these receptors have effects on neurotransmitters such as serotonin?

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TheAnswerPage

JUNE 18, 2022

Has the terpenoid caryophyllene, which is found in the cannabis plant, been found to significantly reduce cravings for cigarettes? Yes, according to one study with significant findings (P. Rose JE, Behm FM. Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. Drug Alcohol Depend. 1994 Feb;34(3):225-9.

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TheAnswerPage

MAY 22, 2022

The FDA has issued a document with full prescribing information for a CBD product, Epidiolex. According to this document, are there any blood tests that should be performed prior to initiating treatment with Epidiolex?

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TheAnswerPage

AUGUST 23, 2022

A June 2022 research study conducted in Ontario Canada (where cannabis-based medicine is legal at the federal level), assessed how chronic pain patients view the use of cannabis-based products for medicinal purposes. Do you think that most patients viewed cannabinoid-based therapeutics as an effective pain remedy?

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TheAnswerPage

JULY 7, 2022

According to an anonymous, cross-sectional online survey conducted in May 2021 that involved 2,697 adult Canadian federally-authorized medical cannabis patients, many patients substituted cannabis-based products for pharmaceutical drugs. What percentage used cannabis-based products as a substitute? alcohol, tobacco/nicotine).

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TheAnswerPage

MAY 13, 2021

What are the common modes of administration of medical marijuana used by cancer patients? According to a survey completed by 183 cancer patients of an oncology clinic at Sutter Medical Center in Sacramento, California, over 50% reported use of oils and tinctures and 44% used edibles.

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TheAnswerPage

APRIL 14, 2021

Are cannabis and marijuana the same thing? Actually, no. Cannabis is a flowering plant, while marijuana is defined as a substance composed of parts of the Cannabis sativa plant, including the leaves, flowers, seeds, and the resin extracted from any part of the plant. Medical Marijuana: the continuing story. Ann Intern Med.2001;

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TheAnswerPage

APRIL 15, 2023

What is “hashish”? Hashish is a crude product made up of compacted sticky resin glands of the cannabis plant. The popularity of hashish has been diminished by the availability of cannabis concentrates. Special Report | February 2018. Contemporary Routes of Cannabis Consumption: A Primer for Clinicians.

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TheAnswerPage

AUGUST 7, 2021

Some patients apply CBD topically. Does CBD easily penetrate the skin? Due to CBD’s large size and hydrophobic properties, CBD does not penetrate the skin efficiently, however, permeation-enhancing gels have been developed.

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Epilepsy Topical Treatment CBD 61

TheAnswerPage

APRIL 13, 2021

What is the endocannabinoid system? The endocannabinoid system (ECS) is an internal homeostatic system present in all vertebrates that plays a critical role in the nervous system and regulates multiple physiological processes, including appetite, digestion, mood, coordination, and other processes.

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TheAnswerPage

FEBRUARY 3, 2021

What is the most common qualifying condition reported by medical marijuana patients? Currently and historically the most common qualifying condition reported by medical marijuana patients is chronic pain.

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TheAnswerPage

JULY 17, 2022

Are CBD-rich extracts more effective at reducing seizures compared to purified CBD products? In 2017, researchers performed an analysis of observational clinical studies on the treatment of refractory epilepsy with cannabidiol (CBD)-based products.

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TheAnswerPage

MAY 15, 2022

Is CBD addictive? According to the drug package insert of an FDA-approved CBD product, CBD is not addictive. GW Pharmaceuticals press release: “GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich Biosciences, Inc. Announce That EPIDIOLEX® (cannabidiol) Oral Solution Has Been Descheduled And Is No Longer A Controlled Substance” April 6, 2020.

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TheAnswerPage

APRIL 24, 2022

What is the MORE Act? If passed, “The Marijuana Opportunity Reinvestment and Expungement Act, also known as the MORE Act, would remove marijuana from the controlled substances list, leaving it up to states to set their own laws. ” ABC News: House set to pass legislation decriminalizing marijuana.

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TheAnswerPage

JANUARY 10, 2022

Are blunts and joints the same thing? Blunts and joints are not the same. Blunts consist of marijuana wrapped in tobacco leaves, whereas joints consist of marijuana wrapped in cigarette paper. Cooper ZD, Haney M. Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts.

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TheAnswerPage

JUNE 1, 2021

Have CBD’s effects on human embryonic development been fully evaluated? in excess of 150 mg/kg iv as an acute dose or in excess of 30 mg/kg orally daily for 90 days) were administered.

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TheAnswerPage

MAY 26, 2021

What are K2 and Spice? K2 and Spice are synthetic cannabinoid “designer drugs” that are intended to mimic the effects of THC. These synthetic cannabinoids are sold as “herbal incense” at convenience stores/gas stations, smoke shops and via the internet.

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TheAnswerPage

MAY 5, 2021

Marijuana use is not associated with a decrease in respiratory drive.

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TheAnswerPage

APRIL 25, 2021

What are endocannabinoids? Endocannabinoids (also called endogenous cannabinoids) are endogenous agonists of the receptors to which delta-9- tetrahydrocannabinol (THC) also binds.

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TheAnswerPage

APRIL 22, 2021

True or false? The FDA has approved a CBD product derived from marijuana (not hemp). The FDA has approved Epidiolex (cannabidiol).

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TheAnswerPage

APRIL 3, 2021

Does the dosing of CBD need to be adjusted in patients with liver disease? According to the prescribing information packet of Epidiolex (an FDA-approved CBD product),, dose adjustment is recommended in patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment.

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TheAnswerPage

MARCH 30, 2021

Some patients apply CBD topically. Does CBD easily penetrate the skin? Due to CBD’s large size and hydrophobic properties, CBD does not penetrate the skin efficiently, however, permeation-enhancing gels have been developed.

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Epilepsy Topical Treatment Patients 11

TheAnswerPage

FEBRUARY 23, 2021

To date, has the FDA approved cannabis for the treatment of any psychiatric condition? However, the FDA has approved 1 cannabis-derived medication (CBD) called Epidiolex and 2 cannabis-related medications (dronabinol and nabilone) for specific indications. Dronabinol is a synthetic THC product that is used as an antiemetic agent.

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TheAnswerPage

JANUARY 4, 2021

Describe the exact mechanism of action of Epidiolex. According to the Epidiolex FDA Approved Package Insert, (Greenwich Biosciences, Inc.), the precise mechanism(s) by which Epidiolex exerts its anticonvulsant effects in humans are unknown. It does not appear to be through cannabidiol receptors. See Answer. See Answer.

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Packaging 56

TheAnswerPage

AUGUST 2, 2021

Is the effect of THC on mood dependent upon the dose of THC? Yes – “Evidence from pre-clinical AND clinical studies suggests that THC exhibits biphasic effects on mood, with low doses of THC having anxiolytic and mood-elevating effects and high doses of THC having anxiogenic and mood-lowering effects.” ” [link].

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THC 53

TheAnswerPage

JUNE 9, 2021

Is CBD addictive? According to the drug package insert of an FDA-approved CBD product, CBD is not addictive. GW Pharmaceuticals press release: “GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich Biosciences, Inc. Announce That EPIDIOLEX® (cannabidiol) Oral Solution Has Been Descheduled And Is No Longer A Controlled Substance” April 6, 2020.

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TheAnswerPage

MAY 4, 2021

What is the pharmacokinetic profile of marijuana when it is administered orally? The psychoactive and physiological effects of orally consumed marijuana typically appear approximately 90 minutes after ingestion, reach their maximum after 2-3 hours and last for about 4-12 hours.

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TheAnswerPage

APRIL 25, 2021

What are terpenes ? Terpenes are aromatic hydrocarbons and just like the phytocannabinoids, terpenes are manufactured in the glands of the cannabis flower. Terpenes may influence the uptake and effects of phytocannabinoids. The terpenes found in cannabis include limonene, pinene, myrcene, delta-3-carene, eucalyptol and humulene.

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TheAnswerPage

APRIL 9, 2021

What is the most common qualifying condition reported by medical marijuana patients? Currently and historically, the most common qualifying condition reported by medical marijuana patients is chronic pain.

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TheAnswerPage

MARCH 24, 2021

If a patient uses a CBD product, will a THC drug screen be positive? The answer to this question depends on 2 things: 1. Is the patient consuming pure CBD or full spectrum CBD. Full spectrum CBD contains multiple cannabinoids, including THC.) The sensitivity of the drug screening test. See Answer. See Answer.

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TheAnswerPage

MARCH 21, 2021

What are some of the heavy metals that may be present in some cannabinoid preparations? Heavy metals, such as arsenic, cadmium, lead and mercury may be present in cannabinoid-based products. It is important to look at a certificate of analysis to determine if heavy metals have been detected in a product. See Answer. See Answer.

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Cannabinoids 53

TheAnswerPage

MARCH 19, 2021

Does raw cannabis flower contain CBD or CBDA? The raw flower contains CBDA (the acid form of cannabidiol). When the raw cannabis material is heated via vaporization, smoking or baking, the CBDA is converted to CBD. See Answer. See Answer.

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