The Cannigma

JUNE 20, 2021

One clinical trial published in 2015 found “significantly higher blood THC” values among test subjects who consumed alcohol with cannabis, which they said could “possibly explain increased performance impairment observed from cannabis-alcohol combinations.” The same terpenes are present in fresh herbs like basil as well as in cannabis.

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Food Terpenes Cannabinoids Clinical Trials 145

Puff Puff Post

JANUARY 13, 2020

Generally speaking, 99 cent stores sell CBD that doesn’t have its terpenes or other cannabinoids measured. Terpenes are the chemicals that give cannabis varieties their unique flavor or scent. Terpenes interact with both cannabidiol and THC and change the effects that either drug has on the body. Physicians at Mt.

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CBD Clinical Trials Research and Development Oil 52

Puff Puff Post

JANUARY 13, 2020

Generally speaking, 99 cent stores sell CBD that doesn’t have its terpenes or other cannabinoids measured. Terpenes are the chemicals that give cannabis varieties their unique flavor or scent. Terpenes interact with both cannabidiol and THC and change the effects that either drug has on the body. Physicians at Mt.

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CBD Clinical Trials Research and Development Oil 52

MedicalJane

MAY 21, 2020

Animal studies are not only valuable, they can also be superior to clinical trials in some cases because they can circumvent human biases and expectancy effects, or perceptual and cognitive reactions to participation in cannabis-based experiments. Hemp” is defined in the Act as “the plant Cannabis sativa L.

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Oil Hemp Extraction Clinical Trials 100

Veriheal

APRIL 11, 2022

In particular, of all the components contained in the cannabis plant— including cannabinoids , terpenes , and flavonoids — the cannabis compound tetrahydrocannabinol (THC) has proven to harbor medicinal benefits when used in specific formulations. The debate surrounding cannabis’ potentially therapeutic powers has ensued for decades.

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Pharmaceutical Research and Development DEA Clinical Trials 104

The Cannigma

JULY 1, 2022

Because of this variability in the plant, and because of a lack of standard methods–like chemical analyses of cannabinoids or terpenes–has led to inconsistent scientific results. This is because these types of studies control the most variables to ensure that the results that come out of the trial are as reliable as possible.

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Research and Development Data THC Clinical Trials 108

The Joint Blog

JANUARY 23, 2020

” The systematic review of the literature “was conducted during 2019, assessing the data from all case studies and clinical trials involving medicinal cannabis or plant-derived isolates for all major psychiatric disorders (neurological conditions and pain were omitted).”

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Clinical Trials Sleep Marijuana Cannabinoids 52

Miss Marijuana

MAY 13, 2020

A Certificate of Analysis (COA) shows the product was made properly, does not contain pesticides or heavy metals (and verifies CBD content as well as other compounds, such as terpenes). Full spectrum means that the product contains most of the naturally occurring cannabinoids and terpenes of the plant. So which one works best?

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CBD Blood Pressure Clinical Trials Tincture 98

CannaMD

SEPTEMBER 28, 2020

For example, high-CBD strains are also high in myrcene , a sedating terpene compound. Scientists have also studied combinations of THC and CBD, such as Sativex clinical trials that show patients’ marked improvement in sleep. Research is complex because there are compounding factors.

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Sleep Clinical Trials Patients THC 72

FloridaMarijuana.net

OCTOBER 9, 2018

In 2017, The National Academies of Sciences, Engineering, and Medicine published a statement that the use of cannabis for the treatment of pain is supported by “well-controlled clinical trials and that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.”.

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Canna Care Docs

JUNE 22, 2018

THC is simply one cannabinoid present within cannabis that interacts with many other cannabinoids present within the plant, including aromatic terpenes which all contribute to what is known as the entourage effect.

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THC Patients Blood Pressure Clinical Trials 66

The Cannigma

JUNE 24, 2021

While more human clinical trials are needed, the current evidence suggests there may be potential therapeutic benefits for the following ailments: Chronic pain — the most common reason people turn to medical cannabis in the United States today. But when taken together, these chemicals are thought to work greater in concert.

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CBD Microdosing Edibles Sleep 75

MMJ Recs

DECEMBER 28, 2023

Medical marijuana, especially strains with high levels of the terpene myrcene and sedating indica varieties, has shown promise in promoting sleep. Cannabis for Insomnia: Understanding Its Sleep-Inducing Properties Insomnia is a common sleep disorder that can significantly impact daily functioning and overall well-being.

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Conditions Chronic Pain Epilepsy Research and Development 98

Sensi Seeds

NOVEMBER 23, 2018

However, recent research on the cannabinoid and terpene profiles of different cannabis varieties mean we need to reassess what we thought we know about indicas and sativas being defined by their THC:CBD ratio. And yet others swear by hybrids, for the best of both worlds. What type of cannabis will make you laugh?

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Blood Pressure Indica Clinical Trials Sativa 81

Miss Marijuana

MARCH 15, 2021

The rich smell provided by the pinene and myrcene terpenes make this flower a breath of fresh air for those looking for a strain with earthy tones for the nostrils. Many people tout this strain’s powerful effect on their lives, and it will be curious to see what the medical community does once clinical trials are initiated.

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Greencamp

AUGUST 16, 2018

Even though these effects were observed on mice, all mammals have neurological and cellular similarities, and the team in charge of this study concluded that: “With respect to the treatment of ALS, from both a disease modifying and symptom management viewpoint, clinical trials with cannabis are the next logical step.

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Strains Cannabinoids Research and Development Indica 94

Miss Marijuana

MAY 13, 2020

A Certificate of Analysis (COA) shows the product was made properly, does not contain pesticides or heavy metals (and verifies CBD content as well as other compounds, such as terpenes). Full spectrum means that the product contains most of the naturally occurring cannabinoids and terpenes of the plant. So which one works best?

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CBD Blood Pressure Clinical Trials Tincture 52

CannaTech

SEPTEMBER 16, 2018

Over time extended clinical trials will continue to map out the plant’s therapeutic effects, supporting it as an alternative medicine offering relief for a long list of conditions. There simply isn’t enough research on cannabis to support its efficacy, especially in comparison to traditional medicine like opioids.

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Education Medicine Clinical Trials Patients 66

SpeedWeed

AUGUST 4, 2021

We will be investing heavily in research and development and clinical trials to develop a full range of medicines, ready for registration and marketing authorization in Australia and Europe. . Our initial product line will include a range of high THC flower, oils, tablets, and terpenes. View original article.

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Chronic Pain Research and Development Medicine Supply Chain 52

The Cannigma

DECEMBER 12, 2022

Clinical research: Research is focusing on 5-MeO-DMT use in depression and anxiety. Current clinical trials are underway using a synthetic nasal spray of 5-MeO-DMT in patients with major depressive disorder. As such, there have been numerous clinical trials using ketamine.

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History Microdosing Research and Development Clinical Trials 119

TheAnswerPage

JANUARY 11, 2022

the components of the cannabis plant (phytocannabinoids, terpenes, and flavonoids) and the health effects of cannabinoid-based therapy in the various patient populations. Results of an observational study merely suggest an association between a therapeutic agent or an event and an outcome.

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Patients Education Marijuana Therapy 98

Project CBD

OCTOBER 26, 2023

They conducted a double-blind, placebo-controlled phase 2 clinical trial using Sativex® in conjunction with temozolomide to treat recurrent glioblastoma multiforme (GBM). See chapter: Cannabinoids, Terpenes & Flavonoids ). 21,22 ( See chapter: Cannabinoids, Terpenes & Flavonoids ).

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Research and Development Cannabinoids Terpenes Pharmaceutical 343

Otherside Farms

NOVEMBER 3, 2019

CBD isolate is the perfect example of the absence of the entourage effect, and that’s why people are beginning to enhance it with terpenes. The second most talked-about aspect of the entourage effect is how it is affected by terpenes. Alpha-pinene is a terpene commonly found in cannabis and is said to inhibit acetylcholinesterase.

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Terpenes CBD Research and Development Cannabinoids 58

CannaMD

AUGUST 8, 2020

Prior to receiving FDA approval, Epidiolex underwent a number of clinical trials establishing the medical efficacy of CBD. Hemp oil also lacks critical terpenes and other secondary cannabinoids found in cannabis oil. According to Project CBD : A huge amount of industrial hemp is required to extract a small amount of CBD.

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CBD DEA Research and Development Hemp 99

The Cannigma

JUNE 15, 2021

This means that all cannabinoids (including trace amounts of THC), terpenes, flavonoids, and other phytonutrients present in the plant are preserved and used in the final product. With the exception of THC, all cannabinoids, terpenes, flavonoids, and other phytonutrients are preserved and used in the final product.

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CBD Research and Development Epilepsy Extraction 122

Veriheal

SEPTEMBER 6, 2022

Recent research has found that terpene and cannabinoid profiles are far more significant when trying to produce specific effects. Terpene and cannabinoid profiles of the cannabis you are consuming will also impact the effects experienced. Indica has a reputation for making people feel calm and mellow and helping to induce sleep.

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Sleep THC CBD Chronic Pain 90

Project CBD

MAY 3, 2023

Dr. Goldstein: We don’t have clinical trials to say, yes this is definitively beneficial or detrimental for children. But we may be on the cusp of having those trials, which would be very exciting. CannMed: I’m glad you brought up ADHD. Full disclosure: my son has been diagnosed with ADHD.

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Cannabinoids Sleep Clinical Trials CBD 209

Alchimia

JANUARY 25, 2022

Assuming clinical trials go well, the ultimate hope of the researchers is to develop a pill containing purified versions of these acidic cannabinoids as an adjunct to vaccination, for use after known exposure or by those who are immunocompromised. Why does CBD work best when combined with other cannabinoids and terpenes?

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Research and Development Terpenes CBD Treatment 98

The Joint Blog

FEBRUARY 18, 2020

” Clinical trial data published in 2017 in in the journal European Neuropsychopharmacology previously reported that the administration of whole-plant cannabis extracts is associated with improvements in cognition and behavior in subjects with ADHD. 9-tetrahydrocannabinol (THC).

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Clinical Trials Terpenes Data Cannabinoids 45

The Cannigma

APRIL 8, 2021

Now, you’re talking about just 12 potential active therapeutic cannabinoids, then you can talk about, do the same thing through terpenes. That there’s not enough information about, there’s not enough clinical trials, and there’s not enough this and that. Why we’ve seen those side effect profiles? That’s one way. I think it’s 21.

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Medicine Cannabinoids Cannabis THC 108

Cannabis Law Report

AUGUST 12, 2019

Broad spectrum CBD oil contains a variety of active compounds such as cannabinoids and terpenes, which we will discuss in greater detail in Section 2. Most industrial hemp is grown for its fiber and contains relatively small concentrations of cannabinoids and terpenes, so it is not the most desirable source of CBD oil.

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CBD Terpenes Oil Tincture 40

The Cannigma

FEBRUARY 11, 2021

Listen & Subscribe: When Mara Gordon started using medical cannabis there wasn’t any lab testing — or any way to know how much of each cannabinoid or terpene was in a given strain. You know, started doing clinical trials through Zelda Therapeutics, and all the other things I’ve done. So I just started doing it myself.

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Wellness and Beauty Data Patients Medicine 125

Cannabis Law Report

NOVEMBER 7, 2019

With a strong focus on research and development ranging from agronomic research through to clinical trials Cannatrek has an extensive R&D portfolio from Seed to Patient. Cannatrek is actively working on clinical trial protocols with a dedicated focus on mental health.

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Medicine Patients Research and Development Clinical Trials 40

Green Relief

MAY 13, 2018

As yet there have been no FDA -approved clinical trials to determine the efficacy of CBD -rich cannabis oil extracts for traumatic brain injury. Thus far, however, there have been no FDA -sanctioned clinical trials to ascertain the efficacy of whole plant, CBD -rich cannabis oil for traumatic brain injury.

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THC CBD Cannabinoids Research and Development 64

Green Relief

MAY 12, 2018

As yet there have been no FDA -approved clinical trials to determine the efficacy of CBD -rich cannabis oil extracts for traumatic brain injury. Thus far, however, there have been no FDA -sanctioned clinical trials to ascertain the efficacy of whole plant, CBD -rich cannabis oil for traumatic brain injury.

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Research and Development Cannabinoids Therapy CBD 40

The Cannigma

DECEMBER 22, 2021

I do want to say that when it comes to anxiety, sleep, I mean, what we do, for example, in Bazelet, which is quite unique, as far as oil products are concerned, this is something that is we have a lot of intellectual property on the use of terpenes in creating cannabis formulations. We have, I think, eight PhDs.

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Research and Development Oil Cannabis Clinical Trials 79

The Cannigma

MARCH 12, 2021

And he’s looking at it and all these words are coming out, cannabinoids, THC, CBD, ratios, terpenes, and the customer realizes they have no idea what they’re doing. They want also maybe CBD and they want terpenes and they want other cannabinoids in there. and those are intertwined in – they do want THC, but not just THC.

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