Medical Cannabis Brief

Dr. Andrew Weil on Cannabis and Integrative Medicine

Project CBD

NOVEMBER 11, 2023

Dr. Andrew Weil is the founder and director of the Arizona Center for Integrative Medicine at the University of Arizona College of Medicine. His early publications ( The Natural Mind and From Chocolate to Morphine ) focused on exploring altered states of consciousness. He is the author of several bestselling books, including Spontaneous Healing (1995), Eating Well for Optimum Health (2000), and Healthy Aging (2007).

Medicine

Medicine Research and Development Pharmaceutical Cannabis

ICRS 2023: Report from Toronto

Project CBD

AUGUST 9, 2023

I counted over 175 talks and posters at the 33rd annual gathering of the International Cannabinoid Research Society (ICRS), which convened in Toronto at the end of June. In accordance with longstanding ICRS policy, all speakers presented new findings and data that had not yet been published in a peer-reviewed journal. But this year’s 4-day ICRS conference was notable not only for its cutting-edge science.

Cannabinoids

Cannabinoids THC CBD Blood Pressure

Expert Gives Delta-8 THC Thumbs Down

Project CBD

JULY 28, 2023

Dr. Mark A. Scialdone, a recognized expert in the field of organic chemistry who specializes in natural product chemistry, is an inventor of 37 issued US patents and the author of 17 peer-reviewed articles in science publications. From 1994 to 2013, he was employed as a principal investigator at DuPont Central Research and Development. Dr. Scialdone is a founding member of the Cannabis Chemistry Subdivision of the American Chemical Society from which he received the 2018 CANN-CHAS Heidolph Award

THC

THC Cannabinoids Hemp Research and Development

Gut Feeling

Project CBD

JUNE 20, 2023

Pain, anxiety, and sleep are major drivers of medical cannabis use. But gastrointestinal symptoms, such as nausea and upset stomach, aren’t far behind. 1 Even small doses of cannabis can soothe the stomach and stimulate the appetite. In fact, of the four cannabis-derived drugs approved so far by the U.S. Food and Drug Administration, three are prescribed for the treatment of chemotherapy-induced nausea and vomiting.

Cannabinoids

Cannabinoids Patients Treatment Conditions

Dumpster Fire: What Went Wrong with CA Cannabis?

Project CBD

JUNE 16, 2023

Cannabis is supposed to be relaxing and fun. What’s not to like about giggles, munchies, and a brief break from the mundane? Unfortunately, the news from California’s Emerald Triangle is anything but upbeat these days. Report after report portends doom with headlines like “the world’s largest legal weed market is going up in smoke ” (The Economist), “California pot industry facing ‘ extinction event ‘” (SF Gate), and “ Despair in Emerald Triangle as CA legal cannabis collapses” (CalM

Supply Chain

Supply Chain Retail Cultivation Cannabis

Beta-Caryophyllene: Terpene Powerhouse

Project CBD

JUNE 7, 2023

Project CBD recently reported on studies indicating that cannabis terpenes — the compounds that give the plant its robust and distinctive smell — activate the CB1 cannabinoid receptor. What’s more, in the presence of THC (also a CB1 agonist), terpenes appear to modulate cannabinoid activity in varied and interesting ways. 1,2 Today we focus on spicy-peppery beta-caryophyllene (BCP), one of the most common cannabis terpenes, which acts on several targets that impact the endocannabinoi

Terpenes

Terpenes Chronic Pain Cannabinoids Food

Which Terpenes Enhance the Cannabis High?

Project CBD

MAY 24, 2023

Ten years ago, most cannabis consumers couldn’t tell a terpene from a cannabinoid. But today things are different. Cannabis flower is categorized according to terpene profile. Product manufacturers add terp blends back into edibles and concentrates. Limonene is practically a household name. And for good reason. Sure, terpenes impart desirable flavors and aromas.

Terpenes

Terpenes THC Cannabinoids Concentrates

Psychedelic Research Potpourri

Project CBD

MAY 10, 2023

Recently I was chatting with a friend who is casually interested in psychedelic science. He told me he hadn’t read as much coverage of psychedelics in popular magazines and other mainstream outlets lately, and asked whether research has slowed. My response? Not at all. According to Pubmed, the online repository of the National Library of Medicine, last year saw far more papers published on psychedelics than ever before — about 33% more than in 2021, which itself was a 19% increase over 202

Microdosing

Microdosing Research and Development Treatment Therapy

Cannabichromene, a Minor Cannabinoid with Major Upside

Project CBD

MAY 3, 2023

In 2013, Noriko Shinjyo, Ph.D., a Research Associate at Chiba University in Japan, coauthored a study with Italian scientist Vincenzo Di Marzo on cannabichromene (CBC), a phytocannabinoid that exerts profound effects on the nervous system. 1 Published in Neurochemistry International , their paper probed how CBC influences the fate of adult neural stem progenitor cells, which are described as “an essential component of brain function in health as well as in pathology.” As stem cells m

Cannabinoids

Cannabinoids Research and Development THC Terpenes

Getting to Know Cannabigerol with Bonni Goldstein, MD

Project CBD

MAY 3, 2023

This transcript is adapted from CannMed’s weekly podcast , hosted by Ben Amirault, who recently interviewed Bonni Goldstein, MD, one of the country’s most respected and experienced medical cannabis physicians. Dr. Goldstein has treated thousands of patients with medical cannabis. She is the medical director of Canna-Centers Wellness & Education and the clinical advisor to Cannformatics.

Cannabinoids

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Project CBD Launches New Website Developed in Collaboration with Blue Dream

Project CBD

APRIL 4, 2023

If you’ve been to our website before, you’ll see it’s much easier to navigate now, thanks to the talented folks at Blue Dream , Ganjapreneur’s in-house creative agency. You’ll also see that we have significantly increased our medical conditions-related content. “The new Project CBD website is designed to make their educational content more accessible and discoverable,” explained Noel Abbott, CEO of Ganjapreneur and strategic advisor for Blue Dream. ̶

CBD

CBD Education Policy Conditions

Project CBD Launches New Website Developed in Collaboration with Blue Dream

Project CBD

MAY 2, 2023

If you’ve been to our website before, you’ll see it’s much easier to navigate now, thanks to the talented folks at Blue Dream , Ganjapreneur’s in-house creative agency. You’ll also see that we have significantly increased our medical conditions-related content. “The new Project CBD website is designed to make their educational content more accessible and discoverable,” explained Noel Abbott, CEO of Ganjapreneur and strategic advisor for Blue Dream. ̶

CBD

CBD Education Policy Conditions

CBD Enhances Glucose Metabolism via Nuclear Receptors

Project CBD

APRIL 26, 2023

Cannabinoid receptors CB1 and CB2 are the definitive and best-known targets of endogenous and plant-derived cannabinoids, but they’re far from the only ones. Several phytocannabinoids, including cannabidiol (CBD), for example, and the two primary endocannabinoids — anandamide and 2-AG — have been shown to interact with peroxisome proliferator-activated receptors, or PPARs 1 (pronounced pee-parrs ), which are found on the surface of the cell’s nucleus.

CBD

CBD Treatment Cannabinoids Medicine

THC & CBD-Rich Cannabis for Fibromyalgia

Project CBD

FEBRUARY 27, 2023

For all modern medicine can do, many mysteries remain unsolved. What is long COVID? Is there really such thing as a “cure” for cancer? And how to explain the surprisingly high prevalence of fibromyalgia, a debilitating, lifelong disorder of the central nervous system without a known cause that affects between 2 and 4 percent of adults worldwide? In the absence of an answer — or a cure — treatment is the name of the game for fibromyalgia.

THC

THC CBD Sleep Clinical Trials

CBD Market Report

Project CBD

FEBRUARY 28, 2023

HerbalGram, the acclaimed quarterly journal of the American Botanical Council, recently published its 2021 “Herb Market Report,” which included data on sales of CBD as an herbal ingredient in mainstream and natural retail channels in the United States. The combined total from both channels — $58,293,034 — does not include CBD sales in licensed cannabis dispensaries or CBD products, such as vapes, tinctures, gummies, and other edibles sold online.

CBD

CBD Seed-To-Sale Food Access

Celtic Hemp

Project CBD

MARCH 7, 2023

Have you heard of Celtic Hemp? In a recently published paper in Cannabis and Cannabinoid Research , Dr. John M. McPartland and Saoirse E. O’Sullivan trace hemp’s prehistoric journey from Asia to Hibernia — now modern-day Ireland. Like much of Europe, cannabis arrived in Ireland when written records were scarce. The authors rely on archeological, linguistic, and pollen analyses as they document the migration of cannabis across Europe.

Hemp

Hemp History Sativa Cannabinoids

Ode to a Vanishing Handcraft

Project CBD

MARCH 7, 2023

At first glance, Cannabis Textiles is a quiet, unassuming book, without slick, staged photos or superlative descriptions of indigenous cultures. Such simplicity reflects the book’s inner beauty, which documents the history of a disappearing handcraft, that of traditional hemp cultivation and fabric production. Skoglund’s book focuses primarily on indigenous hemp cultures in Europe and Asia.

Hemp

Hemp History Wellness and Beauty CBD

Mechoulam on the Future of Cannabinoid Research

Project CBD

MARCH 15, 2023

I was fortunate to cross paths with Raphael Mechoulam, “the father of cannabis research,” at several science conferences over the years. The most memorable occasion was the 22nd annual meeting of the International Cannabinoid Research Society (ICRS) in Freiburg, Germany, in July 2012. Mechoulam delivered a plenary speech at the symposium, addressing the future of cannabinoid research and key areas of study that should be pursued.

Cannabinoids

Cannabinoids Research and Development CBD THC

Cannabinoids for Tinnitus?

Project CBD

MARCH 21, 2023

Recently my wife returned from a night out with a ringing in one ear and significantly diminished hearing. It was a sure sign of injury caused by standing too close to a speaker. She was upset with herself for being so careless and concerned that the condition would persist. For the next couple days, she got extra sleep to aid recovery, and for good measure took an extra dose or two of CBD.

Cannabinoids

Cannabinoids Clinical Trials Sleep Blood Pressure

Cancer & the CB2 Receptor

Project CBD

MARCH 29, 2023

The cannabinoid receptor CB1, primary target of THC in the brain, is known for mediating the cannabis high. And its counterpart CB2, mainly expressed in immune cells throughout the body, is understood to play an important role in inflammatory processes. These abstractions are accurate as far as they go, but as with anything related to the endocannabinoid system, reality is far more complex.

Research and Development

Research and Development Cannabinoids CBD THC

Mental Health & the CB2 Receptor

Project CBD

APRIL 5, 2023

In the first part of this series, we reviewed recent research into the role of the CB2 cannabinoid receptor in cancer proliferation. This week we turn our attention to another fascinating aspect of CB2 function: its impact on psychiatric and mood disorders despite not being concentrated in the central nervous system (CNS). After all, the CNS is the domain of its sibling, the CB1 cannabinoid receptor — the primary target of THC and the mediator of cannabis’ intoxicating effects.

Cannabinoids

Cannabinoids CBD Therapy Concentrates

Downstream Effects: April 2023

Project CBD

APRIL 11, 2023

This is first of an occasional column that updates developments pertaining to articles previously published by Project CBD. We start with some positive news from the Golden State. Then a follow-up on our investigative report about Curaleaf, the world’s biggest cannabis company. And freedom of expression takes a hit when it comes to cannabis advocacy in the Czech Republic.

Supply Chain

Supply Chain Environment CBD Cultivation

The Plant, the Whole Plant & Nothing But the Plant

Project CBD

APRIL 11, 2023

It has long been known that resinous cannabis flower tops are infused with robust therapeutic properties. But there are also pharmacologically active components in other parts of the plant that shouldn’t be ignored when assessing the health benefits of cannabis. The earliest reference to the therapeutic use of cannabis dates back to 2700 BC in ancient China, “ the land of hemp and mulberry.

Wellness and Beauty

Wellness and Beauty Medicine Cannabinoids Hemp

Cancer & the CB2 Receptor

Project CBD

MARCH 29, 2023

A compound in cauliflower, cabbage, broccoli, Brussels sprouts, and other leafy greens exerts anti-cancer effects through the endocannabinoid system.

CBD for Tinnitus?

Project CBD

MARCH 21, 2023

Exploring a novel treatment for phantom sounds.

CBD

CBD Treatment

Cannabinoids for Tinnitus?

Project CBD

MARCH 21, 2023

Exploring a novel treatment for phantom sounds.

Cannabinoids

Cannabinoids Treatment

Mechoulam on the Future of Cannabinoid Research

Project CBD

MARCH 15, 2023

Raphael Mechoulam, the father of cannabis science, emphasized three key research areas to prioritize.

Cannabinoids

Cannabinoids Cannabis

Celtic Hemp

Project CBD

MARCH 7, 2023

Scholars document how cannabis came to Ireland.

Hemp

Hemp Cannabis

Ode to a Vanishing Handcraft

Project CBD

MARCH 7, 2023

A review of Cannabis Textiles in Hemp Garden Cultures by Git Skoglund.

Hemp

Hemp Cannabis

PEA: Anti-Inflammatory Superstar

Project CBD

FEBRUARY 21, 2023

PEA , a lipid neurotransmitter known as the “endogenous CBD ,” is a powerhouse against inflammation and pain.

CBD

Outdoor or Indoor Grown Cannabis: What's the Difference?

Project CBD

FEBRUARY 14, 2023

New study comparing outdoor and indoor grown cannabis finds variations in phytochemical production.

Cannabis

Curaleaf Controversies

Project CBD

FEBRUARY 6, 2023

Curaleaf, the world’s largest cannabis company, is mired in scandals involving Russian oligarch money, product safety violations, and unfair labor practices.

Safety

Safety Cannabis